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Prevalence of streptomycin and tetracycline resistance and increased transmissible third-generation cephalosporin resistance in Salmonella enterica isolates derived from food handlers in Japan from 2006 to 2021
https://hiroshima.repo.nii.ac.jp/records/2040747
https://hiroshima.repo.nii.ac.jp/records/2040747819ba351-9bac-4009-aa29-90f073a2a632
| 名前 / ファイル | ライセンス | アクション |
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JAM_135_9.pdf (467 KB)
Download is available from 2025/9/10.
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| Item type | デフォルト(1) | |||||||||||||||
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| 公開日 | 2025-06-17 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Prevalence of streptomycin and tetracycline resistance and increased transmissible third-generation cephalosporin resistance in Salmonella enterica isolates derived from food handlers in Japan from 2006 to 2021 | |||||||||||||||
| 言語 | en | |||||||||||||||
| 作成者 |
Ohata, Natsuki
× Ohata, Natsuki
× Noda, Mamoru
× Ohta, Kenji
× Hatta, Moritaka
× Nakayama, Tatsuya
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| アクセス権 | ||||||||||||||||
| アクセス権 | embargoed access | |||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_f1cf | |||||||||||||||
| 権利情報 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 権利情報 | This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Applied Microbiology following peer review. The version of record [Natsuki Ohata, Mamoru Noda, Kenji Ohta, Moritaka Hatta, Tatsuya Nakayama, Prevalence of streptomycin and tetracycline resistance and increased transmissible third-generation cephalosporin resistance in Salmonella enterica isolates derived from food handlers in Japan from 2006 to 2021, Journal of Applied Microbiology, Volume 135, Issue 9, September 2024, lxae236,] is available online at: https://doi.org/10.1093/jambio/lxae236. | |||||||||||||||
| 権利情報 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 権利情報 | This is not the published version. Please cite only the published version. | |||||||||||||||
| 権利情報 | ||||||||||||||||
| 言語 | ja | |||||||||||||||
| 権利情報 | この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 | |||||||||||||||
| 主題 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Japanese food handlers | |||||||||||||||
| 主題 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Salmonella | |||||||||||||||
| 主題 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | streptomycin and tetracycline | |||||||||||||||
| 主題 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | blaCMY-2 | |||||||||||||||
| 主題 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | blaCTX-M-14 | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Aims The increasing prevalence of AmpC β-lactamase (AmpC)- and extended-spectrum β-lactamase (ESBL)- producing food pathogens is a serious public health concern. AmpC- and ESBL-producing Salmonella species pose a high risk of food contamination. This study aimed to investigate changes in the prevalence of Salmonella among food handlers in Japan from 2006 to 2021 using 100 randomly selected isolates from 2006, 2012, 2018, and 2021 with different serotypes and antimicrobial resistance patterns. Methods and results The average Salmonella isolation rate was 0.070% (19 602/27 848 713). Serotyping revealed that the most common serotypes were Enteritidis in 2006, Infantis in 2012, Agoueve/Cubana in 2018, and Schwarzengrund in 2021. Antimicrobial susceptibility testing showed that Salmonella isolates exhibited the highest resistance to streptomycin (<40%), followed by tetracycline (<20%–40%). Moreover, 6% of the Salmonella isolates produced cephalosporinases with the blaCMY-2, blaCTX-M-14, and blaTEM genes. The annual incidence of cephalosporin resistance has increased. Plasmid conjugation assays revealed that cephalosporin-resistant Salmonella spp. transmitted their resistance to Escherichia coli. Additionally, plasmid genome analysis showed that the insertion sequence IS26 was encoded in the upstream and downstream regions of blaCTX-M-14 and qnrS1 in the IncHI1 plasmid, which could be transmitted to other bacteria. Conclusions The tested Salmonella isolates showed high resistance to specific antibiotics, with differences in resistance depending on the serotype. Further increase and spread of transmissible cephalosporin-resistant strains should be noted. |
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| 言語 | en | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Oxford University Press | |||||||||||||||
| 言語 | en | |||||||||||||||
| 日付 | ||||||||||||||||
| 日付 | 2025-09-10 | |||||||||||||||
| 日付タイプ | Available | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | AM | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||
| 関連情報 | ||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.1093/jambio/lxae236 | |||||||||||||||
| 助成情報 | ||||||||||||||||
| 助成機関識別子タイプ | Crossref Funder | |||||||||||||||
| 助成機関識別子タイプURI | https://doi.org/10.13039/501100001691 | |||||||||||||||
| 助成機関名 | 日本学術振興会 | |||||||||||||||
| 言語 | ja | |||||||||||||||
| 助成機関名 | Japan Society for the Promotion of Science | |||||||||||||||
| 言語 | en | |||||||||||||||
| 研究課題番号URI | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18KK0168/ | |||||||||||||||
| 研究課題番号 | 18KK0168 | |||||||||||||||
| 研究課題名 | ベトナム南部における食中毒原因菌の薬剤耐性化に関する調査研究 | |||||||||||||||
| 言語 | ja | |||||||||||||||
| 研究課題名 | Study on the prevalence of antibiotic resistance in foodborne bacterial pathogens in southern Vietnam | |||||||||||||||
| 言語 | en | |||||||||||||||
| 書誌情報 |
en : Journal of Applied Microbiology 巻 135, 号 9, p. lxae236, 発行日 2024-09-10 |
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| 言語 | en | |||||||||||||||
| 値 | The full-text file will be made open to the public on 10 September 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving' | |||||||||||||||
