{"created":"2025-06-17T07:43:38.657492+00:00","id":2040747,"links":{},"metadata":{"_buckets":{"deposit":"09a1be45-e680-4cf0-8704-ca60647ed22c"},"_deposit":{"created_by":79,"id":"2040747","owner":"79","owners":[79],"pid":{"revision_id":0,"type":"depid","value":"2040747"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02040747","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Prevalence of streptomycin and tetracycline resistance and increased transmissible third-generation cephalosporin resistance in Salmonella enterica isolates derived from food handlers in Japan from 2006 to 2021","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohata, Natsuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Noda, Mamoru"}]},{"creatorNames":[{"creatorName":"Ohta, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hatta, Moritaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakayama, Tatsuya","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"embargoed access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_f1cf"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Applied Microbiology following peer review. The version of record [Natsuki Ohata, Mamoru Noda, Kenji Ohta, Moritaka Hatta, Tatsuya Nakayama, Prevalence of streptomycin and tetracycline resistance and increased transmissible third-generation cephalosporin resistance in Salmonella enterica isolates derived from food handlers in Japan from 2006 to 2021, Journal of Applied Microbiology, Volume 135, Issue 9, September 2024, lxae236,] is available online at: https://doi.org/10.1093/jambio/lxae236.","subitem_rights_language":"en"},{"subitem_rights":"This is not the published version. Please cite only the published version.","subitem_rights_language":"en"},{"subitem_rights":"この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。","subitem_rights_language":"ja"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Japanese food handlers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Salmonella","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"streptomycin and tetracycline","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"blaCMY-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"blaCTX-M-14","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Aims\nThe increasing prevalence of AmpC β-lactamase (AmpC)- and extended-spectrum β-lactamase (ESBL)- producing food pathogens is a serious public health concern. AmpC- and ESBL-producing Salmonella species pose a high risk of food contamination. This study aimed to investigate changes in the prevalence of Salmonella among food handlers in Japan from 2006 to 2021 using 100 randomly selected isolates from 2006, 2012, 2018, and 2021 with different serotypes and antimicrobial resistance patterns.\n\nMethods and results\nThe average Salmonella isolation rate was 0.070% (19 602/27 848 713). Serotyping revealed that the most common serotypes were Enteritidis in 2006, Infantis in 2012, Agoueve/Cubana in 2018, and Schwarzengrund in 2021. Antimicrobial susceptibility testing showed that Salmonella isolates exhibited the highest resistance to streptomycin (<40%), followed by tetracycline (<20%–40%). Moreover, 6% of the Salmonella isolates produced cephalosporinases with the blaCMY-2, blaCTX-M-14, and blaTEM genes. The annual incidence of cephalosporin resistance has increased. Plasmid conjugation assays revealed that cephalosporin-resistant Salmonella spp. transmitted their resistance to Escherichia coli. Additionally, plasmid genome analysis showed that the insertion sequence IS26 was encoded in the upstream and downstream regions of blaCTX-M-14 and qnrS1 in the IncHI1 plasmid, which could be transmitted to other bacteria.\n\nConclusions\nThe tested Salmonella isolates showed high resistance to specific antibiotics, with differences in resistance depending on the serotype. Further increase and spread of transmissible cephalosporin-resistant strains should be noted.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"}]},"item_1617186660861":{"attribute_name":"Date","attribute_value_mlt":[{"subitem_date_issued_datetime":"2025-09-10","subitem_date_issued_type":"Available"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186901218":{"attribute_name":"Funding Reference","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"18KK0168","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18KK0168/"},"subitem_award_titles":[{"subitem_award_title":"ベトナム南部における食中毒原因菌の薬剤耐性化に関する調査研究","subitem_award_title_language":"ja"},{"subitem_award_title":"Study on the prevalence of antibiotic resistance in foodborne bacterial pathogens in southern Vietnam","subitem_award_title_language":"en"}],"subitem_funder_identifiers":{"subitem_funder_identifier_type":"Crossref Funder","subitem_funder_identifier_type_uri":"https://doi.org/10.13039/501100001691"},"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-09-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageStart":"lxae236","bibliographicVolumeNumber":"135","bibliographic_titles":[{"bibliographic_title":"Journal of Applied Microbiology","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1093/jambio/lxae236","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-09-10"}],"fileDate":[{"fileDateType":"Available","fileDateValue":"2025-09-10"}],"filename":"JAM_135_9.pdf","filesize":[{"value":"467 KB"}],"format":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2040747/files/JAM_135_9.pdf"},"version_id":"f5206b53-30a7-4055-9001-c67ec189dd8d"}]},"item_1732772494514":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"The full-text file will be made open to the public on 10 September 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving'"}]},"item_title":"Prevalence of streptomycin and tetracycline resistance and increased transmissible third-generation cephalosporin resistance in Salmonella enterica isolates derived from food handlers in Japan from 2006 to 2021","item_type_id":"40036","owner":"79","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-06-17"},"publish_date":"2025-06-17","publish_status":"0","recid":"2040747","relation_version_is_last":true,"title":["Prevalence of streptomycin and tetracycline resistance and increased transmissible third-generation cephalosporin resistance in Salmonella enterica isolates derived from food handlers in Japan from 2006 to 2021"],"weko_creator_id":"79","weko_shared_id":-1},"updated":"2025-06-17T08:04:21.285045+00:00"}