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The Effect of Green Tea Epigallocatechin-3-Gallate on Spatial Memory Function, Malondialdehyde and TNF-α Level in D-Galactose-Induced BALB/C Mice
https://hiroshima.repo.nii.ac.jp/records/2013763
https://hiroshima.repo.nii.ac.jp/records/2013763f779f525-e2cb-432c-b845-9bc103ec6c1b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_67s_41.pdf (575.3 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | The Effect of Green Tea Epigallocatechin-3-Gallate on Spatial Memory Function, Malondialdehyde and TNF-α Level in D-Galactose-Induced BALB/C Mice | |||||||||||||
| 言語 | en | |||||||||||||
| 作成者 |
Gumay, Ainun Rahmasari
× Gumay, Ainun Rahmasari
× Bakri, Saekhol
× Pudjonarko, Dwi
× Suprihati
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| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||
| 権利情報 | ||||||||||||||
| 権利情報 | Copyright (c) 2018 Hiroshima University Medical Press | |||||||||||||
| 主題 | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Green tea epigallocatechin-3-gallate | |||||||||||||
| 主題 | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | spatial memory function | |||||||||||||
| 主題 | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | MDA | |||||||||||||
| 主題 | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | TNF- α | |||||||||||||
| 主題 | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | D- galactose | |||||||||||||
| 主題 | ||||||||||||||
| 主題Scheme | NDC | |||||||||||||
| 主題 | 490 | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述 | Introduction : Neuroinflammatory process and oxidative stress play an important role in the mechanism of brain aging and neurodegenerative diseases such as Alzheimer. Epigallocatechin-3-gallate (EGCG) have antioxidant, anti-inflammatory, and neuroprotective effects. This study aims to prove the effect of green tea EGCG on spatial memory function, malondialdehyde (MDA), and TNF-α level in Balb/c mice induced by D-galactose. Method : An experimental study using "post test only control group design". The samples were 18 male Balb/c mices, aged 6-8 weeks, divided into 3 groups. Negative control group (N-C) was induced by subcutaneous injection of D-galactose (150 mg/kg) once daily for 6 weeks. EGCG-2 and EGCG-6 were induced by D-galactose and orally administered by 2 and 6 mg/kg EGCG once daily for 5 weeks. The indicator of examination were spatial memory function using morris water maze, MDA and TNF-α level using Elisa. One-way Anova, Kruskal-Wallis, and Pearson were used for statistical analysis. Results : Means of % escape latency time and path length in the EGCG-2 {42,02(SD=5,9);43,47(SD=5,97)%} and EGCG-6 {40,45(SD=6,5); 41,78(SD=6,77)%} were significantly higher than N-C {28,68(SD=9,15), p=0,013; 32,98(SD=7,75)%,p=0,04}. MDA level in the EGCG-2 {587,79(SD=76,04)ng/ml} was significantly smaller than N-C {722,64(SD=134,78)ng/ml,p=0,037}. TNF-α level in all groups was not different (p=0,786). There was a significant and strong correlation between MDA level and spatial memory function (r=-0.551; p=0,018). Conclusion : EGCG may improve spatial memory function and oxidative stress in mice induced dementia, but it may not improve the status of neuroinflammation. | |||||||||||||
| 言語 | en | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | Hiroshima University Medical Press | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0018-2052 | |||||||||||||
| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AA00664312 | |||||||||||||
| 開始ページ | ||||||||||||||
| 開始ページ | 41 | |||||||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 67, p. 41-48, 発行日 2018-05 |
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| 旧ID | 45842 | |||||||||||||
