{"created":"2025-02-23T06:42:53.663707+00:00","id":2013763,"links":{},"metadata":{"_buckets":{"deposit":"08ce54d2-5932-4583-8057-48676d3ca5cb"},"_deposit":{"created_by":41,"id":"2013763","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013763"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013763","sets":["1727147343679:1730442224523:1730442235519"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"The Effect of Green Tea Epigallocatechin-3-Gallate on Spatial Memory Function, Malondialdehyde and TNF-α Level in D-Galactose-Induced BALB/C Mice","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Gumay, Ainun Rahmasari","creatorNameLang":"en"}],"familyNames":[{"familyName":"Gumay","familyNameLang":"en"}],"givenNames":[{"givenName":"Ainun Rahmasari","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Bakri, Saekhol","creatorNameLang":"en"}],"familyNames":[{"familyName":"Bakri","familyNameLang":"en"}],"givenNames":[{"givenName":"Saekhol","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Pudjonarko, Dwi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Pudjonarko","familyNameLang":"en"}],"givenNames":[{"givenName":"Dwi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Suprihati","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2018 Hiroshima University Medical Press"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Green tea epigallocatechin-3-gallate","subitem_subject_scheme":"Other"},{"subitem_subject":"spatial memory function","subitem_subject_scheme":"Other"},{"subitem_subject":"MDA","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF- α","subitem_subject_scheme":"Other"},{"subitem_subject":"D- galactose","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Introduction : Neuroinflammatory process and oxidative stress play an important role in the mechanism of brain aging and neurodegenerative diseases such as Alzheimer. Epigallocatechin-3-gallate (EGCG) have antioxidant, anti-inflammatory, and neuroprotective effects. This study aims to prove the effect of green tea EGCG on spatial memory function, malondialdehyde (MDA), and TNF-α level in Balb/c mice induced by D-galactose. Method : An experimental study using \"post test only control group design\". The samples were 18 male Balb/c mices, aged 6-8 weeks, divided into 3 groups. Negative control group (N-C) was induced by subcutaneous injection of D-galactose (150 mg/kg) once daily for 6 weeks. EGCG-2 and EGCG-6 were induced by D-galactose and orally administered by 2 and 6 mg/kg EGCG once daily for 5 weeks. The indicator of examination were spatial memory function using morris water maze, MDA and TNF-α level using Elisa. One-way Anova, Kruskal-Wallis, and Pearson were used for statistical analysis. Results : Means of % escape latency time and path length in the EGCG-2 {42,02(SD=5,9);43,47(SD=5,97)%} and EGCG-6 {40,45(SD=6,5); 41,78(SD=6,77)%} were significantly higher than N-C {28,68(SD=9,15), p=0,013; 32,98(SD=7,75)%,p=0,04}. MDA level in the EGCG-2 {587,79(SD=76,04)ng/ml} was significantly smaller than N-C {722,64(SD=134,78)ng/ml,p=0,037}. TNF-α level in all groups was not different (p=0,786). There was a significant and strong correlation between MDA level and spatial memory function (r=-0.551; p=0,018). Conclusion : EGCG may improve spatial memory function and oxidative stress in mice induced dementia, but it may not improve the status of neuroinflammation.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University Medical Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"41"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"48","bibliographicPageStart":"41","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_67s_41.pdf","filesize":[{"value":"575.3 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013763/files/HiroshimaJMedSci_67s_41.pdf"},"version_id":"9e0b6195-da31-44b1-af09-4897a4da27a7"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"45842"},"item_title":"The Effect of Green Tea Epigallocatechin-3-Gallate on Spatial Memory Function, Malondialdehyde and TNF-α Level in D-Galactose-Induced BALB/C Mice","item_type_id":"40003","owner":"41","path":["1730442235519"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013763","relation_version_is_last":true,"title":["The Effect of Green Tea Epigallocatechin-3-Gallate on Spatial Memory Function, Malondialdehyde and TNF-α Level in D-Galactose-Induced BALB/C Mice"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T03:32:22.937858+00:00"}