| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Effect of FC43se on Endotoxin-induced Disseminated Intravascular Coagulation in Rats |
|
言語 |
en |
| 作成者 |
Ochikubo, Hiroyuki
Wada, Seishi
Sugawara, Yuji
Sueda, Taijiro
Matsuura, Yuichiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Perfiuorocarbons |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Disseminated intravascular coagulation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Cytokine |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Endotoxin |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Perfluorotributylamine/Pluronic F68 Stem-Emulsion (FC43se), which is a blood substitute, was assessed for its effectiveness on disseminated intravascular coagulation (DIC) in the rat model. Rats were infused intravenously with 2.5 mg/kg of Escherichia coli lipopolysaccharide (Escherichia coli 055:B5 lipopolysaccharide B) for four hours. At the same time, FC43se or normal physiological saline was infused at 2.5 ml/kg/hr. The white blood cell and platelet counts, prothrombin time (PT), activated partial thromboplastin time (APTT), and the plasma levels of interleukin-1 beta (IL-1β), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor alpha (TNFα) were determined at 4hr. The infusion of FC43se markedly prevented a decrease in platelet counts (p=0.0004) and a prolongation of both PT and APTT (p<0.05 and p<0.03 each). The serum level of IL-1βand IL-4 showed no significant change. The serum level of IL-6, IL-10 and TNFα increased significantly (p=0.0007, p=0.0004 and p<0.05 each) with infusion of FC43se in rats treated with bacterial endotoxin. FC43se has beneficial effects on endotoxin-induced DIC as an anticoagulant and anti-inflammatory cytokine induced agent. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
71 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 48,
号 2,
p. 71-77,
発行日 1999-06
|
| 旧ID |
37733 |
HiroshimaJMedSci_48_71.pdf (739.1 KB)
