{"created":"2025-02-23T06:33:58.593209+00:00","id":2013460,"links":{},"metadata":{"_buckets":{"deposit":"900a86fc-289a-465c-a9c3-9b52e8b862f9"},"_deposit":{"created_by":41,"id":"2013460","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013460"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013460","sets":["1727147343679:1730442224523:1730442296887"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Effect of FC43se on Endotoxin-induced Disseminated Intravascular Coagulation in Rats","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ochikubo, Hiroyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ochikubo","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroyuki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Wada, Seishi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Wada","familyNameLang":"en"}],"givenNames":[{"givenName":"Seishi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sugawara, Yuji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sugawara","familyNameLang":"en"}],"givenNames":[{"givenName":"Yuji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sueda, Taijiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sueda","familyNameLang":"en"}],"givenNames":[{"givenName":"Taijiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsuura, Yuichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Matsuura","familyNameLang":"en"}],"givenNames":[{"givenName":"Yuichiro","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Perfiuorocarbons","subitem_subject_scheme":"Other"},{"subitem_subject":"Disseminated intravascular coagulation","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytokine","subitem_subject_scheme":"Other"},{"subitem_subject":"Endotoxin","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Perfluorotributylamine/Pluronic F68 Stem-Emulsion (FC43se), which is a blood substitute, was assessed for its effectiveness on disseminated intravascular coagulation (DIC) in the rat model. Rats were infused intravenously with 2.5 mg/kg of Escherichia coli lipopolysaccharide (Escherichia coli 055:B5 lipopolysaccharide B) for four hours. At the same time, FC43se or normal physiological saline was infused at 2.5 ml/kg/hr. The white blood cell and platelet counts, prothrombin time (PT), activated partial thromboplastin time (APTT), and the plasma levels of interleukin-1 beta (IL-1β), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor alpha (TNFα) were determined at 4hr. The infusion of FC43se markedly prevented a decrease in platelet counts (p=0.0004) and a prolongation of both PT and APTT (p<0.05 and p<0.03 each). The serum level of IL-1βand IL-4 showed no significant change. The serum level of IL-6, IL-10 and TNFα increased significantly (p=0.0007, p=0.0004 and p<0.05 each) with infusion of FC43se in rats treated with bacterial endotoxin. FC43se has beneficial effects on endotoxin-induced DIC as an anticoagulant and anti-inflammatory cytokine induced agent.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University Medical Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"71"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"77","bibliographicPageStart":"71","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_48_71.pdf","filesize":[{"value":"739.1 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013460/files/HiroshimaJMedSci_48_71.pdf"},"version_id":"2427f803-e653-4b5d-8df2-744e8d60dfff"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"37733"},"item_title":"Effect of FC43se on Endotoxin-induced Disseminated Intravascular Coagulation in Rats","item_type_id":"40003","owner":"41","path":["1730442296887"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013460","relation_version_is_last":true,"title":["Effect of FC43se on Endotoxin-induced Disseminated Intravascular Coagulation in Rats"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T03:12:00.790164+00:00"}