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Inhibitory Effects of Dopamine on Noradrenaline-induced Constriction of Arterioles in vivo in the Striated Cremaster Muscle
https://hiroshima.repo.nii.ac.jp/records/2013313
https://hiroshima.repo.nii.ac.jp/records/201331308e8767c-2765-4b6b-886e-98a765cfa9db
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_42_1.pdf (1.3 MB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Inhibitory Effects of Dopamine on Noradrenaline-induced Constriction of Arterioles in vivo in the Striated Cremaster Muscle | |||||||
| 言語 | en | |||||||
| 作成者 |
Matsubayashi, Hiroaki
× Matsubayashi, Hiroaki
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Dopamine | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Noradrenaline-induced constriction | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Forskolin | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Arteriole in rat cremaster | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | The effect of dopamine on the arterioles (50.8 ~ 95.2 μm) in the cremaster muscle was examined to determine its effect on microcirculation. Anesthetized rats were used under a light microscope connected to a videocamera. Drugs were applied using small round filter paper (370 μm in diameter) containing the drug and placed in the immediate vicinity of the arteriole on the cremaster with a micromanipulator. The dose of the drug applied was represented by concentration of the drug solution in which the filter paper was immersed. Dopamine (10-6 ~10-4M) induced neither constriction nor dilation of the arteriole in the cremaster. Papaverine (10-2M) did not dilate the arteriole. However, the arterioles were constricted by noradrenaline (10-6 ~ 10-4M) and vasopressin (10-7M) in a dose-dependent manner. Noradrenaline (10-4M)-induced constriction was blocked by concomitant application of dopamine (10-4M). This effect of dopamine was antagonized by SCH23390 (10-3M). However, isoproterenol (10-3M) did not affect the arteriole, nor inhibit noradrenaline (10-4M)-induced constriction of the arterioles. While forskolin (10-2M) alone did not produce constriction or dilation of the arterioles, it inhibited noradrenaline (10-4M)-induced constriction of the arteriole. These results suggest that dopamine prevents the constriction of the arteriole induced by noradrenaline, by activation of DA 1 receptors, which activates adenylate cyclase. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | Hiroshima University Medical Press | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 8486519 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0018-2052 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00664312 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 1 | |||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 42, 号 1, p. 1-7, 発行日 1993-03 |
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| 旧ID | 37910 | |||||||
