{"created":"2025-02-23T06:29:42.608614+00:00","id":2013313,"links":{},"metadata":{"_buckets":{"deposit":"e4cf4d50-c1ce-4839-a26c-3e74e9115d3a"},"_deposit":{"created_by":41,"id":"2013313","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013313"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013313","sets":["1727147343679:1730442224523:1730442317857"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Inhibitory Effects of Dopamine on Noradrenaline-induced Constriction of Arterioles in vivo in the Striated Cremaster Muscle","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsubayashi, Hiroaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Matsubayashi","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroaki","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Dopamine","subitem_subject_scheme":"Other"},{"subitem_subject":"Noradrenaline-induced constriction","subitem_subject_scheme":"Other"},{"subitem_subject":"Forskolin","subitem_subject_scheme":"Other"},{"subitem_subject":"Arteriole in rat cremaster","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The effect of dopamine on the arterioles (50.8 ~ 95.2 μm) in the cremaster muscle was examined to determine its effect on microcirculation. Anesthetized rats were used under a light microscope connected to a videocamera. Drugs were applied using small round filter paper (370 μm in diameter) containing the drug and placed in the immediate vicinity of the arteriole on the cremaster with a micromanipulator. The dose of the drug applied was represented by concentration of the drug solution in which the filter paper was immersed. Dopamine (10-6 ~10-4M) induced neither constriction nor dilation of the arteriole in the cremaster. Papaverine (10-2M) did not dilate the arteriole. However, the arterioles were constricted by noradrenaline (10-6 ~ 10-4M) and vasopressin (10-7M) in a dose-dependent manner. Noradrenaline (10-4M)-induced constriction was blocked by concomitant application of dopamine (10-4M). This effect of dopamine was antagonized by SCH23390 (10-3M). However, isoproterenol (10-3M) did not affect the arteriole, nor inhibit noradrenaline (10-4M)-induced constriction of the arterioles. While forskolin (10-2M) alone did not produce constriction or dilation of the arterioles, it inhibited noradrenaline (10-4M)-induced constriction of the arteriole. These results suggest that dopamine prevents the constriction of the arteriole induced by noradrenaline, by activation of DA 1 receptors, which activates adenylate cyclase.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University Medical Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"1"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"8486519","subitem_relation_type_select":"PMID"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_42_1.pdf","filesize":[{"value":"1.3 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013313/files/HiroshimaJMedSci_42_1.pdf"},"version_id":"3715bab5-9aac-44d3-ae1c-db5150f8417a"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"37910"},"item_title":"Inhibitory Effects of Dopamine on Noradrenaline-induced Constriction of Arterioles in vivo in the Striated Cremaster Muscle","item_type_id":"40003","owner":"41","path":["1730442317857"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013313","relation_version_is_last":true,"title":["Inhibitory Effects of Dopamine on Noradrenaline-induced Constriction of Arterioles in vivo in the Striated Cremaster Muscle"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T03:04:24.623885+00:00"}