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Cytoprotective Activity of Components of Garlic, Ginseng and Ciuwjia on Hepatocyte Injury Induced by Carbon Tetrachloride In Vitro
https://hiroshima.repo.nii.ac.jp/records/2013038
https://hiroshima.repo.nii.ac.jp/records/201303859469d83-2211-453d-b3c5-0a9f4dbb9729
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_34_303.pdf (728.4 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Cytoprotective Activity of Components of Garlic, Ginseng and Ciuwjia on Hepatocyte Injury Induced by Carbon Tetrachloride In Vitro | |||||||||||||||
| 言語 | en | |||||||||||||||
| 作成者 |
NAKAGAWA, Shizutoshi
× NAKAGAWA, Shizutoshi
× YOSHIDA, Susumu
× HIRAO, Yuzo
× KASUGA, Shigeo
× FUWA, Tohru
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| アクセス権 | ||||||||||||||||
| アクセス権 | open access | |||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||
| 主題 | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Antihepatotoxic activity | |||||||||||||||
| 主題 | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Cysteine compounds from garlic | |||||||||||||||
| 主題 | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Ginsenosides | |||||||||||||||
| 主題 | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Syringaresinol | |||||||||||||||
| 主題 | ||||||||||||||||
| 主題Scheme | NDC | |||||||||||||||
| 主題 | 490 | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述 | The antihepatotoxic activity of ten components related to plants were investigated using freshly isolated hepatocytes which maintained specific liver functions such as glucagon-dependent glycogenolysis and albumin producibility. Six components of garlic, i.e., S-methyl cysteine, S-ethyl cysteine, S-propyl cysteine, S-allylmercapto cysteine, alliin and S-allyl cysteine, and two syringaresinols of ciuwjia were synthesized. Two ginsenosides were purified from extract of ginseng. Both syringaresinols and S-allyl cysteine at concentrations of 250ng/ml and 0.5μg/ml, respectively, completely suppressed cytotoxicity on hepatocytes by CC14, as judged from GPT level released in the culture medium and morphology of the hepatocytes in stained specimens. The same was observed with S-propyl cysteine, S-allylmercapto cysteine and two ginsenosides at concentrations of lOμg/ml or less. Alliin was also effective but suppressed only GPT leakage. Four positive control drugs used was less effective. S-methyl cysteine and S-ethyl cysteine showed no obvious effect in any concentrations. | |||||||||||||||
| 言語 | en | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| 関連情報 | ||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||
| 関連識別子 | 4066397 | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 0018-2052 | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA00664312 | |||||||||||||||
| 開始ページ | ||||||||||||||||
| 開始ページ | 303 | |||||||||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 34, 号 3, p. 303-309, 発行日 1985-09 |
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| 旧ID | 49869 | |||||||||||||||
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NAKAGAWA, Shizutoshi, YOSHIDA, Susumu, HIRAO, Yuzo, KASUGA, Shigeo, FUWA, Tohru, n.d., Cytoprotective Activity of Components of Garlic, Ginseng and Ciuwjia on Hepatocyte Injury Induced by Carbon Tetrachloride In Vitro: Hiroshima University School of Medicine, 303– p.
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