{"created":"2025-02-23T06:21:46.859412+00:00","id":2013038,"links":{},"metadata":{"_buckets":{"deposit":"1fba111e-5c09-41c9-b9b2-dd866256267e"},"_deposit":{"created_by":41,"id":"2013038","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2013038"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02013038","sets":["1727147343679:1730442224523:1730442336483"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Cytoprotective Activity of Components of Garlic, Ginseng and Ciuwjia on Hepatocyte Injury Induced by Carbon Tetrachloride In Vitro","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAKAGAWA, Shizutoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"NAKAGAWA","familyNameLang":"en"}],"givenNames":[{"givenName":"Shizutoshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"YOSHIDA, Susumu","creatorNameLang":"en"}],"familyNames":[{"familyName":"YOSHIDA","familyNameLang":"en"}],"givenNames":[{"givenName":"Susumu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"HIRAO, Yuzo","creatorNameLang":"en"}],"familyNames":[{"familyName":"HIRAO","familyNameLang":"en"}],"givenNames":[{"givenName":"Yuzo","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"KASUGA, Shigeo","creatorNameLang":"en"}],"familyNames":[{"familyName":"KASUGA","familyNameLang":"en"}],"givenNames":[{"givenName":"Shigeo","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"FUWA, Tohru","creatorNameLang":"en"}],"familyNames":[{"familyName":"FUWA","familyNameLang":"en"}],"givenNames":[{"givenName":"Tohru","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Antihepatotoxic activity","subitem_subject_scheme":"Other"},{"subitem_subject":"Cysteine compounds from garlic","subitem_subject_scheme":"Other"},{"subitem_subject":"Ginsenosides","subitem_subject_scheme":"Other"},{"subitem_subject":"Syringaresinol","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The antihepatotoxic activity of ten components related to plants were investigated using freshly isolated hepatocytes which maintained specific liver functions such as glucagon-dependent glycogenolysis and albumin producibility. Six components of garlic, i.e., S-methyl cysteine, S-ethyl cysteine, S-propyl cysteine, S-allylmercapto cysteine, alliin and S-allyl cysteine, and two syringaresinols of ciuwjia were synthesized. Two ginsenosides were purified from extract of ginseng. Both syringaresinols and S-allyl cysteine at concentrations of 250ng/ml and 0.5μg/ml, respectively, completely suppressed cytotoxicity on hepatocytes by CC14, as judged from GPT level released in the culture medium and morphology of the hepatocytes in stained specimens. The same was observed with S-propyl cysteine, S-allylmercapto cysteine and two ginsenosides at concentrations of lOμg/ml or less. Alliin was also effective but suppressed only GPT leakage. Four positive control drugs used was less effective. S-methyl cysteine and S-ethyl cysteine showed no obvious effect in any concentrations.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hiroshima University School of Medicine"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0018-2052","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00664312","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"開始ページ","attribute_value_mlt":[{"subitem_start_page":"303"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1985-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"309","bibliographicPageStart":"303","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Hiroshima Journal of Medical Sciences"},{"bibliographic_title":"Hiroshima Journal of Medical Sciences"}]}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"4066397","subitem_relation_type_select":"PMID"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HiroshimaJMedSci_34_303.pdf","filesize":[{"value":"728.4 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2013038/files/HiroshimaJMedSci_34_303.pdf"},"version_id":"434b9fc3-0d6f-4ff4-9b8f-c2c435d3fcef"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"49869"},"item_title":"Cytoprotective Activity of Components of Garlic, Ginseng and Ciuwjia on Hepatocyte Injury Induced by Carbon Tetrachloride In Vitro","item_type_id":"40003","owner":"41","path":["1730442336483"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2013038","relation_version_is_last":true,"title":["Cytoprotective Activity of Components of Garlic, Ginseng and Ciuwjia on Hepatocyte Injury Induced by Carbon Tetrachloride In Vitro"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-02T02:55:05.871844+00:00"}