| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2019-06-07 |
| タイトル |
|
|
タイトル |
Retinoic acid controls vascular formation by activating transcription of aryl hydrocarbon receptor gene in medakafish Oryzias latipes |
|
言語 |
en |
| 作成者 |
Sada, Naotaka
Hanafusa, Takahiro
Onizuka, Yuichi
Hayashida, Yasufumi
Kageyama, Shota
Yamashita, Ichiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2019 by Authors |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
arly hydrocarbon receptor |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
common cardinal vein |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
retinoic acid |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
retinoic acid receptor |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
medakafish |
| 内容記述 |
|
|
内容記述 |
Retinoic acid (RA) has been shown to have a role in vascular formation, but how it affects is not fully understood. Previously, we reported that RA and its nuclear receptor (RAR) is required for transcription of ahr1 encoding an aryl hydrocarbon receptor (AHR), and that pharmacological modulation of RA, RAR, and AHR impairs the formation of common cardinal veins (CCVs) on the yolk of medakafish embryos. Here, to delineate a role for ahr1 in the vascular formation, we used an antisense-ahr1 mRNA to suppress ahr1. Following the development of vegfr1-expressing angioblast cells, we show that the antisense-ahr1 greatly inhibited the accumulation of angioblasts at the prospective branchial arch (PBA) where CCVs begin to develop on the yolk and the following CCV formation, demonstrating for the first time the essential role of ahr1 in the embryonic vascular formation of vertebrates. We also show that rarα and ahr1 mRNAs are co-expressed at PBA, suggesting a possible role of the specific expression. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported in part by a grant from the Ministry of Education, Science, Sports and Culture of Japan. |
| 日付 |
|
|
日付 |
2019-06-07 |
|
日付タイプ |
Created |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_1843 |
|
資源タイプ |
other |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 開始ページ |
|
|
開始ページ |
1 |
| 書誌情報 |
p. 1-26
|
| 旧ID |
47694 |
| 備考 |
未発表原稿 |
Retinoic acid controls vascular formation by activating transcription of aryl hydrocarbon receptor gene in medakafish Oryzias latipes.pdf (1.0 MB)
