{"created":"2025-02-21T06:14:51.176824+00:00","id":2011749,"links":{},"metadata":{"_buckets":{"deposit":"ca5aa664-01f7-4b02-95a1-30d93f0650a7"},"_deposit":{"created_by":41,"id":"2011749","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2011749"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02011749","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Retinoic acid controls vascular formation by activating transcription of aryl hydrocarbon receptor gene in medakafish Oryzias latipes","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sada, Naotaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sada","familyNameLang":"en"}],"givenNames":[{"givenName":"Naotaka","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hanafusa, Takahiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hanafusa","familyNameLang":"en"}],"givenNames":[{"givenName":"Takahiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Onizuka, Yuichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Onizuka","familyNameLang":"en"}],"givenNames":[{"givenName":"Yuichi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hayashida, Yasufumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hayashida","familyNameLang":"en"}],"givenNames":[{"givenName":"Yasufumi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kageyama, Shota","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kageyama","familyNameLang":"en"}],"givenNames":[{"givenName":"Shota","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamashita, Ichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamashita","familyNameLang":"en"}],"givenNames":[{"givenName":"Ichiro","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2019 by Authors"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"arly hydrocarbon receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"common cardinal vein","subitem_subject_scheme":"Other"},{"subitem_subject":"retinoic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"retinoic acid receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"medakafish","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Retinoic acid (RA) has been shown to have a role in vascular formation, but how it affects is not fully understood. Previously, we reported that RA and its nuclear receptor (RAR) is required for transcription of ahr1 encoding an aryl hydrocarbon receptor (AHR), and that pharmacological modulation of RA, RAR, and AHR impairs the formation of common cardinal veins (CCVs) on the yolk of medakafish embryos. Here, to delineate a role for ahr1 in the vascular formation, we used an antisense-ahr1 mRNA to suppress ahr1. Following the development of vegfr1-expressing angioblast cells, we show that the antisense-ahr1 greatly inhibited the accumulation of angioblasts at the prospective branchial arch (PBA) where CCVs begin to develop on the yolk and the following CCV formation, demonstrating for the first time the essential role of ahr1 in the embryonic vascular formation of vertebrates. We also show that rarα and ahr1 mRNAs are co-expressed at PBA, suggesting a possible role of the specific expression.","subitem_description_language":"en"},{"subitem_description":"This work was supported in part by a grant from the Ministry of Education, Science, Sports and Culture of Japan.","subitem_description_type":"Other"}]},"item_1617186660861":{"attribute_name":"Date","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-06-07","subitem_date_issued_type":"Created"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"1"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicPageEnd":"26","bibliographicPageStart":"1"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-06-07"}],"displaytype":"simple","filename":"Retinoic acid controls vascular formation by activating transcription of aryl hydrocarbon receptor gene in medakafish Oryzias latipes.pdf","filesize":[{"value":"1.0 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2011749/files/Retinoic acid controls vascular formation by activating transcription of aryl hydrocarbon receptor gene in medakafish Oryzias latipes.pdf"},"version_id":"58e44d3a-2665-4dfa-b3da-c49023435b64"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"47694"},"item_1732772494514":{"attribute_name":"備考","attribute_value":"未発表原稿"},"item_title":"Retinoic acid controls vascular formation by activating transcription of aryl hydrocarbon receptor gene in medakafish Oryzias latipes","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-06-07"},"publish_date":"2019-06-07","publish_status":"0","recid":"2011749","relation_version_is_last":true,"title":["Retinoic acid controls vascular formation by activating transcription of aryl hydrocarbon receptor gene in medakafish Oryzias latipes"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-22T11:34:52.881968+00:00"}