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Characteristics of High-Molecular-Weight Hyaluronic Acid as a Brain-Derived Neurotrophic Factor Scaffold in Periodontal Tissue Regeneration

https://hiroshima.repo.nii.ac.jp/records/2008980
https://hiroshima.repo.nii.ac.jp/records/2008980
1e4116a5-b630-4748-9eaf-adf400f8e77d
名前 / ファイル ライセンス アクション
TissueEngPartA_17_955.pdf TissueEngPartA_17_955.pdf (1.5 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Characteristics of High-Molecular-Weight Hyaluronic Acid as a Brain-Derived Neurotrophic Factor Scaffold in Periodontal Tissue Regeneration
言語 en
作成者 Takeda, Katsuhiro

× Takeda, Katsuhiro

en Takeda, Katsuhiro

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Sakai, Noriyuki

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en Sakai, Noriyuki

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Shiba, Hideki

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en Shiba, Hideki

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Nagahara, Takayoshi

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en Nagahara, Takayoshi

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Fujita, Tsuyoshi

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en Fujita, Tsuyoshi

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Kajiya, Mikihito

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en Kajiya, Mikihito

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Iwata, Tomoyuki

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en Iwata, Tomoyuki

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Matsuda, Shinji

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en Matsuda, Shinji

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Kawahara, Kazuko

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Kawaguchi, Hiroyuki

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Kurihara, Hidemi

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 This is a copy of an article published in the Tissue engineering, Part A. (c) 2011 Mary Ann Liebert, Inc.; Tissue engineering, Part A. is available online at: http://online.liebertpub.com.
主題
主題Scheme NDC
主題 490
内容記述
内容記述 Brain-derived neurotrophic factor (BDNF), for which bovine collagen-derived atelocollagen is used as a scaffold, enhances periodontal tissue regeneration. However, a scaffold that does not contain unknown ingredients is preferable. Since the synthesized high-molecular-weight (HMW)-hyaluronic acid (HA) is safe and inexpensive, we evaluated the efficacy of HMW-HA as a BDNF scaffold. CD44, a major receptor of HA, was expressed in cultures of human periodontal ligament cells, and HMW-HA promoted the adhesion and proliferation of human periodontal ligament cells, although it did not influence the mRNA expression of bone (cementum)-related proteins. The in vitro release kinetics of BDNF from HMW-HA showed that BDNF release was sustained for 14 days. Subsequently, we examined the effect of BDNF/HMW-HA complex on periodontal tissue regeneration in dogs. A greater volume of newly formed alveolar bone and a longer newly formed cementum were observed in the BDNF/HMW-HA group than in the HMW-HA group, suggesting that HMW-HA assists the regenerative capacity of BDNF, although HMW-HA itself does not enhance periodontal tissue regeneration. Neither the poly (lactic-co-glycolic acid) group nor the BDNF/poly (lactic-co-glycolic acid) group enhanced periodontal tissue regeneration. In conclusion, HMW-HA is an adequate scaffold for the clinical application of BDNF.
言語 en
出版者
出版者 Mary Ann Liebert
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1089/ten.TEA.2010.0070
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1089/ten.TEA.2010.0070
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA12306003
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1937-3341
開始ページ
開始ページ 955
書誌情報 Tissue engineering. Part A.
Tissue engineering. Part A.

巻 17, 号 7-8, p. 955-967, 発行日 2011
旧ID 32031
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