{"created":"2025-02-21T04:40:58.077443+00:00","id":2008980,"links":{},"metadata":{"_buckets":{"deposit":"77b9e059-30d1-4443-80f0-7aeadb3baa75"},"_deposit":{"created_by":41,"id":"2008980","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2008980"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02008980","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Characteristics of High-Molecular-Weight Hyaluronic Acid as a Brain-Derived Neurotrophic Factor Scaffold in Periodontal Tissue Regeneration","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takeda, Katsuhiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takeda","familyNameLang":"en"}],"givenNames":[{"givenName":"Katsuhiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sakai, Noriyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sakai","familyNameLang":"en"}],"givenNames":[{"givenName":"Noriyuki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shiba, Hideki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Shiba","familyNameLang":"en"}],"givenNames":[{"givenName":"Hideki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nagahara, Takayoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nagahara","familyNameLang":"en"}],"givenNames":[{"givenName":"Takayoshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Fujita, Tsuyoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Fujita","familyNameLang":"en"}],"givenNames":[{"givenName":"Tsuyoshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kajiya, Mikihito","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kajiya","familyNameLang":"en"}],"givenNames":[{"givenName":"Mikihito","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Iwata, Tomoyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Iwata","familyNameLang":"en"}],"givenNames":[{"givenName":"Tomoyuki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsuda, Shinji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Matsuda","familyNameLang":"en"}],"givenNames":[{"givenName":"Shinji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kawahara, Kazuko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kawahara","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazuko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kawaguchi, Hiroyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kawaguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroyuki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kurihara, Hidemi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kurihara","familyNameLang":"en"}],"givenNames":[{"givenName":"Hidemi","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"This is a copy of an article published in the Tissue engineering, Part A. (c) 2011 Mary Ann Liebert, Inc.; Tissue engineering, Part A. is available online at: http://online.liebertpub.com."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Brain-derived neurotrophic factor (BDNF), for which bovine collagen-derived atelocollagen is used as a scaffold, enhances periodontal tissue regeneration. However, a scaffold that does not contain unknown ingredients is preferable. Since the synthesized high-molecular-weight (HMW)-hyaluronic acid (HA) is safe and inexpensive, we evaluated the efficacy of HMW-HA as a BDNF scaffold. CD44, a major receptor of HA, was expressed in cultures of human periodontal ligament cells, and HMW-HA promoted the adhesion and proliferation of human periodontal ligament cells, although it did not influence the mRNA expression of bone (cementum)-related proteins. The in vitro release kinetics of BDNF from HMW-HA showed that BDNF release was sustained for 14 days. Subsequently, we examined the effect of BDNF/HMW-HA complex on periodontal tissue regeneration in dogs. A greater volume of newly formed alveolar bone and a longer newly formed cementum were observed in the BDNF/HMW-HA group than in the HMW-HA group, suggesting that HMW-HA assists the regenerative capacity of BDNF, although HMW-HA itself does not enhance periodontal tissue regeneration. Neither the poly (lactic-co-glycolic acid) group nor the BDNF/poly (lactic-co-glycolic acid) group enhanced periodontal tissue regeneration. In conclusion, HMW-HA is an adequate scaffold for the clinical application of BDNF.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Mary Ann Liebert"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"AA12306003","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"1937-3341","subitem_source_identifier_type":"ISSN"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"955"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7-8","bibliographicPageEnd":"967","bibliographicPageStart":"955","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"Tissue engineering. Part A."},{"bibliographic_title":"Tissue engineering. 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