| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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|
タイトル |
Suppression of inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 22(R)-hydroxycholesterol requires de novo protein synthesis in activated macrophages |
|
言語 |
en |
| 作成者 |
Yasuda, Toshimichi
Kanno, Masamoto
Kawamoto, Masashi
Yuge, Osafumi
Ninomiya, Yuichi
|
| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2005 Elsevier Ltd |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
22(R)-Hydroxycholesterol |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Inflammation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Macrophage |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
22R-HC |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
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|
内容記述 |
Liver X receptors (LXRs) play an important role in lipid metabolism. Recently, a role for these proteins was identified in suppressing the inflammatory response. However, it is not known whether the natural ligands of LXRs, e.g. 22(R)-hydroxycholesterol (22R-HC), can suppress the inflammatory response after the onset of inflammation. We demonstrate here that treatment of Lipopolysaccharide (LPS)-activated RAW264.7 macrophages with 22R-HC markedly suppressed nitric oxide (NO) production and inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA expression. Additionally, 22R-HC did not affect the DNA binding activity of NF-κB, AP-1 and C/EBP(s), important transcriptional factors for iNOS and COX-2 genes expression. Furthermore iNOS and COX-2 mRNA suppression by 22R-HC was diminished by cellular treatment with cycloheximide. These results suggest that 22R-HC suppresses the expression of iNOS and COX-2 genes through de novo protein synthesis of an unidentified protein in LPS-activated macrophages. © 2005 Elsevier Ltd. All rights reserved. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier Ltd |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.jsbmb.2005.06.030 |
| 関連情報 |
|
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
16146692 |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.jsbmb.2005.06.030 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0960-0760 |
| 開始ページ |
|
|
開始ページ |
376 |
| 書誌情報 |
The Journal of Steroid Biochemistry and Molecular Biology
The Journal of Steroid Biochemistry and Molecular Biology
巻 97,
号 4,
p. 376-383,
発行日 2005-12
|
| 旧ID |
14745 |
JSBMB_97_4_376.pdf (1.3 MB)
