| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice |
|
言語 |
en |
| 作成者 |
Mizuno, Toshiyuki
Yamasaki, Norimasa
Miyazaki, Kazuko
Tazaki, Tatsuya
Koller, Richard
Oda, Hideki
Honda, Zen-ichiro
Ochi, Mitsuo
Wolff, Linda
Honda, Hiroaki
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2008 Nature Publishing Group |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Chronic myelogenous leukemia |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
CML |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
blast crisis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
BC |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
transgenic mice |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Tg |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
p210BCR/ABL |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Notch1 |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Chronic myelogenous leukemia (CML) is a hematopoietic disorder, which begins as indolent chronic phase but inevitably progresses to fatal blast crisis. p210BCR/ABL, a constitutively active tyrosine kinase, is responsible for disease initiation but molecular mechanism(s) underlying disease evolution remains largely unknown. To explore this process, we employed retroviral insertional mutagenesis to CML-exhibiting p210BCR/ABL transgenic mice (Tg). Virus infection induced acute lymphoblastic leukemia (ALL) in p210BCR/ABL Tg with a higher frequency and in a shorter latency than wild-type littermates, and inverse PCR detected two retrovirus common integration sites (CISs) in p210BCR/ABL Tg tumors. Interestingly, one CIS was the transgene itself, where retrovirus integrations induced upregulation of p210BCR/ABL and production of truncated BCR/ABL with an enhanced kinase activity. Another CIS was Notch1 gene, where retrovirus integrations resulted in overexpression of Notch1 and generation of Notch1 lacking the C-terminal region (Notch1C) associated with stable expression of its activated product, C-terminus-truncated Notch intracellular domain (NICDC). In addition, generation of Tg for both p210BCR/ABL and Notch1C developed ALL in a shortened period with Stat5 activation, demonstrating the cooperative oncogenicity of Notch1C/NICDC with p210BCR/ABL involving Stat5-mediated pathway. These results demonstrated that overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induce acute leukemia in a transgenic model for CML. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Nature Publishing Group |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1038/sj.onc.1211007 |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1038/sj.onc.1211007 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0950-9232 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10687380 |
| 開始ページ |
|
|
開始ページ |
3465 |
| 書誌情報 |
Oncogene
Oncogene
巻 27,
号 24,
p. 3465-3474,
発行日 2008-05
|
| 旧ID |
26304 |
Oncogene_27_3465.pdf (2.7 MB)
