{"created":"2025-02-21T04:06:34.969113+00:00","id":2007899,"links":{},"metadata":{"_buckets":{"deposit":"33645eb3-ed73-41b7-970e-e97c05451158"},"_deposit":{"created_by":41,"id":"2007899","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007899"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007899","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mizuno, Toshiyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Mizuno","familyNameLang":"en"}],"givenNames":[{"givenName":"Toshiyuki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamasaki, Norimasa","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamasaki","familyNameLang":"en"}],"givenNames":[{"givenName":"Norimasa","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miyazaki, Kazuko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Miyazaki","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazuko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tazaki, Tatsuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tazaki","familyNameLang":"en"}],"givenNames":[{"givenName":"Tatsuya","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Koller, Richard","creatorNameLang":"en"}],"familyNames":[{"familyName":"Koller","familyNameLang":"en"}],"givenNames":[{"givenName":"Richard","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Oda, Hideki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Oda","familyNameLang":"en"}],"givenNames":[{"givenName":"Hideki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Honda, Zen-ichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Honda","familyNameLang":"en"}],"givenNames":[{"givenName":"Zen-ichiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ochi, Mitsuo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ochi","familyNameLang":"en"}],"givenNames":[{"givenName":"Mitsuo","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Wolff, Linda","creatorNameLang":"en"}],"familyNames":[{"familyName":"Wolff","familyNameLang":"en"}],"givenNames":[{"givenName":"Linda","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Honda, Hiroaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Honda","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroaki","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2008 Nature Publishing Group"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Chronic myelogenous leukemia","subitem_subject_scheme":"Other"},{"subitem_subject":"CML","subitem_subject_scheme":"Other"},{"subitem_subject":"blast crisis","subitem_subject_scheme":"Other"},{"subitem_subject":"BC","subitem_subject_scheme":"Other"},{"subitem_subject":"transgenic mice","subitem_subject_scheme":"Other"},{"subitem_subject":"Tg","subitem_subject_scheme":"Other"},{"subitem_subject":"p210BCR/ABL","subitem_subject_scheme":"Other"},{"subitem_subject":"Notch1","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Chronic myelogenous leukemia (CML) is a hematopoietic disorder, which begins as indolent chronic phase but inevitably progresses to fatal blast crisis. p210BCR/ABL, a constitutively active tyrosine kinase, is responsible for disease initiation but molecular mechanism(s) underlying disease evolution remains largely unknown. To explore this process, we employed retroviral insertional mutagenesis to CML-exhibiting p210BCR/ABL transgenic mice (Tg). Virus infection induced acute lymphoblastic leukemia (ALL) in p210BCR/ABL Tg with a higher frequency and in a shorter latency than wild-type littermates, and inverse PCR detected two retrovirus common integration sites (CISs) in p210BCR/ABL Tg tumors. Interestingly, one CIS was the transgene itself, where retrovirus integrations induced upregulation of p210BCR/ABL and production of truncated BCR/ABL with an enhanced kinase activity. Another CIS was Notch1 gene, where retrovirus integrations resulted in overexpression of Notch1 and generation of Notch1 lacking the C-terminal region (Notch1C) associated with stable expression of its activated product, C-terminus-truncated Notch intracellular domain (NICDC). In addition, generation of Tg for both p210BCR/ABL and Notch1C developed ALL in a shortened period with Stat5 activation, demonstrating the cooperative oncogenicity of Notch1C/NICDC with p210BCR/ABL involving Stat5-mediated pathway. These results demonstrated that overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induce acute leukemia in a transgenic model for CML.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0950-9232","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10687380","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"3465"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"24","bibliographicPageEnd":"3474","bibliographicPageStart":"3465","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"Oncogene"},{"bibliographic_title":"Oncogene"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/sj.onc.1211007","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1038/sj.onc.1211007","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"Oncogene_27_3465.pdf","filesize":[{"value":"2.7 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007899/files/Oncogene_27_3465.pdf"},"version_id":"b15e804b-a445-4dd3-9139-524a5c8a0efe"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"26304"},"item_title":"Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2007899","relation_version_is_last":true,"title":["Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T11:10:13.267614+00:00"}