Item type |
デフォルトアイテムタイプ_(フル)(1) |
公開日 |
2023-03-18 |
タイトル |
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タイトル |
Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy |
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言語 |
en |
作成者 |
Mitani, Yoshitsugu
Oue, Naohide
Matsumura, Shunji
Yoshida, Kazuhiro
Noguchi, Tsuyoshi
Ito, Masanori
Tanaka, Shinji
Kuniyasu, Hiroki
Kamata, Nobuyuki
Yasui, Wataru
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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権利情報 |
Copyright (c) 2007 Nature Publishing Group. |
主題 |
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主題Scheme |
Other |
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主題 |
Reg IV |
主題 |
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主題Scheme |
Other |
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主題 |
apoptosis |
主題 |
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主題Scheme |
Other |
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主題 |
5-fluorouracil |
主題 |
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主題Scheme |
Other |
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主題 |
serum tumor marker |
主題 |
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主題Scheme |
Other |
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主題 |
SAGE |
主題 |
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主題Scheme |
Other |
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主題 |
gastric cancer |
主題 |
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主題Scheme |
NDC |
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主題 |
490 |
内容記述 |
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内容記述 |
Regenerating gene family, member 4 (Reg IV), a secreted protein, is overexpressed in several cancers, including gastric cancer (GC). In the present study, we measured Reg IV levels in sera from patients with GC by enzyme-linked immunosorbent assay. We also examined the effect of forced Reg IV expression on the apoptotic susceptibility to 5-fluorouracil (5-FU). Forced expression of Reg IV inhibited 5-FU-induced apoptosis. Induction of Bcl-2 and dihydropyrimidine dehydrogenase was involved in inhibition of apoptosis. Among 36 GC patients treated with a combination chemotherapy of low-dose 5-FU and cisplatin, all 14 Reg IV-positive patients showed no change or disease progression. The serum Reg IV concentration was similar between healthy individuals (mean±s.e., 0.52±0.05 ng/ml) and patients with chronic-active gastritis (0.36±0.09 ng/ml). However, the serum Reg IV concentration in presurgical GC patients was significantly elevated (1.96±0.17 ng/ml), even at stage I. The diagnostic sensitivity of serum Reg IV (36.1%) was superior to that of serum carcinoembryonic antigen (11.5%) or carbohydrate antigen 19-9 (13.1%). These results indicate that expression of Reg IV is a marker for prediction of resistance to 5-FU-based chemotherapy in patients with GC. Serum Reg IV represents a novel biomarker for GC. |
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言語 |
en |
出版者 |
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出版者 |
Nature Publishing Group |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
出版タイプ |
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出版タイプ |
AO |
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出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/sj.onc.1210215 |
関連情報 |
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識別子タイプ |
PMID |
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関連識別子 |
17237819 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
http://dx.doi.org/10.1038/sj.onc.1210215 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0950-9232 |
収録物識別子 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10687380 |
開始ページ |
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開始ページ |
4383 |
書誌情報 |
Oncogene
Oncogene
巻 26,
号 30,
p. 4383-4393,
発行日 2007
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旧ID |
20727 |