{"created":"2025-02-21T04:06:34.356759+00:00","id":2007898,"links":{},"metadata":{"_buckets":{"deposit":"9d76ea82-1f9d-4b7f-ad82-daf7f2190365"},"_deposit":{"created_by":41,"id":"2007898","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007898"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007898","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mitani, Yoshitsugu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Mitani","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoshitsugu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Oue, Naohide","creatorNameLang":"en"}],"familyNames":[{"familyName":"Oue","familyNameLang":"en"}],"givenNames":[{"givenName":"Naohide","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsumura, Shunji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Matsumura","familyNameLang":"en"}],"givenNames":[{"givenName":"Shunji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshida, Kazuhiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yoshida","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazuhiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Noguchi, Tsuyoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Noguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"Tsuyoshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ito, Masanori","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ito","familyNameLang":"en"}],"givenNames":[{"givenName":"Masanori","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanaka, Shinji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tanaka","familyNameLang":"en"}],"givenNames":[{"givenName":"Shinji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kuniyasu, Hiroki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kuniyasu","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kamata, Nobuyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kamata","familyNameLang":"en"}],"givenNames":[{"givenName":"Nobuyuki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yasui, Wataru","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yasui","familyNameLang":"en"}],"givenNames":[{"givenName":"Wataru","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2007 Nature Publishing Group."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Reg IV","subitem_subject_scheme":"Other"},{"subitem_subject":"apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"5-fluorouracil","subitem_subject_scheme":"Other"},{"subitem_subject":"serum tumor marker","subitem_subject_scheme":"Other"},{"subitem_subject":"SAGE","subitem_subject_scheme":"Other"},{"subitem_subject":"gastric cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Regenerating gene family, member 4 (Reg IV), a secreted protein, is overexpressed in several cancers, including gastric cancer (GC). In the present study, we measured Reg IV levels in sera from patients with GC by enzyme-linked immunosorbent assay. We also examined the effect of forced Reg IV expression on the apoptotic susceptibility to 5-fluorouracil (5-FU). Forced expression of Reg IV inhibited 5-FU-induced apoptosis. Induction of Bcl-2 and dihydropyrimidine dehydrogenase was involved in inhibition of apoptosis. Among 36 GC patients treated with a combination chemotherapy of low-dose 5-FU and cisplatin, all 14 Reg IV-positive patients showed no change or disease progression. The serum Reg IV concentration was similar between healthy individuals (mean±s.e., 0.52±0.05 ng/ml) and patients with chronic-active gastritis (0.36±0.09 ng/ml). However, the serum Reg IV concentration in presurgical GC patients was significantly elevated (1.96±0.17 ng/ml), even at stage I. The diagnostic sensitivity of serum Reg IV (36.1%) was superior to that of serum carcinoembryonic antigen (11.5%) or carbohydrate antigen 19-9 (13.1%). These results indicate that expression of Reg IV is a marker for prediction of resistance to 5-FU-based chemotherapy in patients with GC. Serum Reg IV represents a novel biomarker for GC.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0950-9232","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10687380","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"4383"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"30","bibliographicPageEnd":"4393","bibliographicPageStart":"4383","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Oncogene"},{"bibliographic_title":"Oncogene"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/sj.onc.1210215","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"17237819","subitem_relation_type_select":"PMID"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1038/sj.onc.1210215","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"Oncogene_26-30_4383.pdf","filesize":[{"value":"591.8 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007898/files/Oncogene_26-30_4383.pdf"},"version_id":"e73549f6-9938-4bbc-9e21-29f85b065f41"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"20727"},"item_title":"Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2007898","relation_version_is_last":true,"title":["Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T11:10:07.905165+00:00"}