| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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タイトル |
Synergistic defect in 60S ribosomal subunit assembly |
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言語 |
en |
| 作成者 |
Nariai, Masanobu
Tanaka, Tomohisa
Okada, Takafumi
Shirai, Chiharu
Horigome, Chihiro
Mizuta, Keiko
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| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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権利情報 |
Copyright (c) 2005 Oxford University Press |
| 内容記述 |
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内容記述 |
Rrs1p, a ribosomal protein L11-binding protein, has an essential role in biogenesis of 60S ribosomal subunits.Weobtained conditionallysynthetic lethal allele with the rrs1-5 mutation and determined that the mutation is in REX1, which encodes anexonuclease. The highly conserved leucine at 305 was substituted with tryptophan in rex1-1. The rex1-1 allele resulted in 30-extended 5S rRNA. Polysome analysis revealed that rex1-1 and rrs1-5 caused a synergistic defect in the assembly of 60S ribosomal subunits. In vivo and in vitro binding assays indicate that Rrs1p interacts with the ribosomal protein L5.5S rRNA complex. The rrs1-5 mutation weakens the interaction between Rrs1p with both L5 and L11. These data suggest that the assembly of L5.5S rRNA on 60S ribosomal subunits coordinates with assembly of L11 via Rrs1p. |
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言語 |
en |
| 出版者 |
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出版者 |
Oxford University Press |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版タイプ |
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|
出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
10.1093/nar/gki772 |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
http://dx.doi.org/10.1093/nar/gki772 |
| 収録物識別子 |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0305-1048 |
| 開始ページ |
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開始ページ |
4553 |
| 書誌情報 |
Nucleic acids research
Nucleic acids research
巻 33,
号 14,
p. 4553-4562,
発行日 2005
|
| 旧ID |
260 |
NAR_33_14_4553-4562_2005.pdf (421.4 KB)
