{"created":"2025-02-21T04:06:16.624010+00:00","id":2007889,"links":{},"metadata":{"_buckets":{"deposit":"7e1e7cf9-7ba0-4299-9c2d-f8a170506119"},"_deposit":{"created_by":41,"id":"2007889","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007889"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007889","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Synergistic defect in 60S ribosomal subunit assembly","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nariai, Masanobu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nariai","familyNameLang":"en"}],"givenNames":[{"givenName":"Masanobu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanaka, Tomohisa","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tanaka","familyNameLang":"en"}],"givenNames":[{"givenName":"Tomohisa","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okada, Takafumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Okada","familyNameLang":"en"}],"givenNames":[{"givenName":"Takafumi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shirai, Chiharu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Shirai","familyNameLang":"en"}],"givenNames":[{"givenName":"Chiharu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Horigome, Chihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Horigome","familyNameLang":"en"}],"givenNames":[{"givenName":"Chihiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mizuta, Keiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Mizuta","familyNameLang":"en"}],"givenNames":[{"givenName":"Keiko","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2005 Oxford University Press"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Rrs1p, a ribosomal protein L11-binding protein, has an essential role in biogenesis of 60S ribosomal subunits.Weobtained conditionallysynthetic lethal allele with the rrs1-5 mutation and determined that the mutation is in REX1, which encodes anexonuclease. The highly conserved leucine at 305 was substituted with tryptophan in rex1-1. The rex1-1 allele resulted in 30-extended 5S rRNA. Polysome analysis revealed that rex1-1 and rrs1-5 caused a synergistic defect in the assembly of 60S ribosomal subunits. In vivo and in vitro binding assays indicate that Rrs1p interacts with the ribosomal protein L5.5S rRNA complex. The rrs1-5 mutation weakens the interaction between Rrs1p with both L5 and L11. These data suggest that the assembly of L5.5S rRNA on 60S ribosomal subunits coordinates with assembly of L11 via Rrs1p.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0305-1048","subitem_source_identifier_type":"ISSN"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"4553"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"14","bibliographicPageEnd":"4562","bibliographicPageStart":"4553","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"Nucleic acids research"},{"bibliographic_title":"Nucleic acids research"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/nar/gki772","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1093/nar/gki772","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"NAR_33_14_4553-4562_2005.pdf","filesize":[{"value":"421.4 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007889/files/NAR_33_14_4553-4562_2005.pdf"},"version_id":"a4bbb369-2aae-433d-9e0a-543eff3c39de"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"260"},"item_title":"Synergistic defect in 60S ribosomal subunit assembly","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2007889","relation_version_is_last":true,"title":["Synergistic defect in 60S ribosomal subunit assembly"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T11:07:56.350510+00:00"}