| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2024-12-18 |
| タイトル |
|
|
タイトル |
Clinical manifestations and outcomes associated with a high 2HELPS2B score in patients with acute impaired consciousness |
|
言語 |
en |
| 作成者 |
Nonaka, Megumi
Neshige, Shuichiro
Ono, Narumi
Yamada, Hidetada
Takebayashi, Yoshiko
Ishibashi, Haruka
Aoki, Shiro
Yamazaki, Yu
Shishido, Takeo
Agari, Dai
Ochi, Kazuhide
Iida, Koji
Maruyama, Hirofumi
|
| アクセス権 |
|
|
アクセス権 |
embargoed access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is not the published version. Please cite only the published version. |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
2HELPS2B score |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Clinical symptoms |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Emergency patients |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Impaired consciousness |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Seizure |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Outcome |
| 内容記述 |
|
|
内容記述 |
Purpose The 2HELPS2B score is an invaluable tool for assessing seizure risk in critically ill patients with unconsciousness. However, this can be challenging for non-epileptologists to use owing to its reliance on electroencephalogram (EEG) analysis. Thus, identifying clinical manifestations associated with high 2HELPS2B scores is crucial. Methods We examined patients who underwent EEG for acute impaired consciousness in the emergency department between 2020 and 2022. We evaluated the clinical manifestations immediately prior to the EEG tests and identified those associated with a 2HELPS2B score ≥ 2. Additionally, we investigated clinical outcomes in accordance with these manifestations and the 2HELPS2B score. Results A total of 78 patients were included in this study. While the median 2HELPS2B score was 1 (range: 0–6), 13 patients (16.6%) showed electrographic/electroclinical seizures or status epilepticus and 16 patients (20.5%) showed ictal-interictal continuum in their EEGs. Abnormal muscle tonus (p = 0.034) and eye deviation (p = 0.021) were Significantly associated with a 2HELPS2B score ≥ 2. The presence of these manifestations (p < 0.001) and a 2HELPS2B score ≥ 2 (p < 0.001) were both significantly associated with a favorable response to anti-seizure medication. Conversely, patients with a 2HELPS2B score ≥ 2 who exhibited these clinical manifestations were more likely to be non-dischargeable (p = 0.053), have prolonged intensive care unit stays (p = 0.002), or require extended ventilator use (p = 0.082). Conclusion Abnormal muscle tonus and eye deviation were significant manifestations compatible with a 2HELPS2B score ≥ 2 and may indicate an increased risk of seizures or the severity of the epileptic condition. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.jns.2024.123174 |
| 助成情報 |
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助成機関名 |
日本学術振興会 |
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言語 |
ja |
|
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研究課題番号URI |
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K16601/ |
|
|
研究課題番号 |
20K16601 |
|
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研究課題名 |
てんかん焦点切除術後の脳機能温存への生態信号限界値：広帯域皮質脳波での探索 |
|
|
言語 |
ja |
| 助成情報 |
|
|
|
助成機関名 |
Japan Society for the Promotion of Science |
|
|
言語 |
en |
|
|
研究課題名 |
Intrinsic brain activities to predict post-operative brain function: wide-band electrocorticographic study |
| 開始ページ |
|
|
開始ページ |
123174 |
| 書誌情報 |
en : Journal of the Neurological Sciences
巻 465,
p. 123174,
発行日 2024-08-10
|
| 旧ID |
55880 |
| 備考 |
The full-text file will be made open to the public on 10 August 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving' |
JNS_465_123174.pdf (3.9 MB)
