{"created":"2025-02-21T03:56:55.341584+00:00","id":2007594,"links":{},"metadata":{"_buckets":{"deposit":"2d27448e-05ce-46c0-8b69-05a2fa6259a0"},"_deposit":{"created_by":41,"id":"2007594","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007594"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007594","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Clinical manifestations and outcomes associated with a high 2HELPS2B score in patients with acute impaired consciousness","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nonaka, Megumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nonaka","familyNameLang":"en"}],"givenNames":[{"givenName":"Megumi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Neshige, Shuichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Neshige","familyNameLang":"en"}],"givenNames":[{"givenName":"Shuichiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ono, Narumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ono","familyNameLang":"en"}],"givenNames":[{"givenName":"Narumi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamada, Hidetada","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamada","familyNameLang":"en"}],"givenNames":[{"givenName":"Hidetada","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takebayashi, Yoshiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takebayashi","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoshiko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishibashi, Haruka","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ishibashi","familyNameLang":"en"}],"givenNames":[{"givenName":"Haruka","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Aoki, Shiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Aoki","familyNameLang":"en"}],"givenNames":[{"givenName":"Shiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamazaki, Yu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamazaki","familyNameLang":"en"}],"givenNames":[{"givenName":"Yu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shishido, Takeo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Shishido","familyNameLang":"en"}],"givenNames":[{"givenName":"Takeo","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Agari, Dai","creatorNameLang":"en"}],"familyNames":[{"familyName":"Agari","familyNameLang":"en"}],"givenNames":[{"givenName":"Dai","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ochi, Kazuhide","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ochi","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazuhide","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Iida, Koji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Iida","familyNameLang":"en"}],"givenNames":[{"givenName":"Koji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Maruyama, Hirofumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Maruyama","familyNameLang":"en"}],"givenNames":[{"givenName":"Hirofumi","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"embargoed access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_f1cf"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"},{"subitem_rights":"This is not the published version. Please cite only the published version.","subitem_rights_language":"en"},{"subitem_rights":"この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。","subitem_rights_language":"ja"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"2HELPS2B score","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Clinical symptoms","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Emergency patients","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Impaired consciousness","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Seizure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Outcome","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Purpose  The 2HELPS2B score is an invaluable tool for assessing seizure risk in critically ill patients with unconsciousness. However, this can be challenging for non-epileptologists to use owing to its reliance on electroencephalogram (EEG) analysis. Thus, identifying clinical manifestations associated with high 2HELPS2B scores is crucial.  Methods  We examined patients who underwent EEG for acute impaired consciousness in the emergency department between 2020 and 2022. We evaluated the clinical manifestations immediately prior to the EEG tests and identified those associated with a 2HELPS2B score ≥ 2. Additionally, we investigated clinical outcomes in accordance with these manifestations and the 2HELPS2B score.  Results  A total of 78 patients were included in this study. While the median 2HELPS2B score was 1 (range: 0–6), 13 patients (16.6%) showed electrographic/electroclinical seizures or status epilepticus and 16 patients (20.5%) showed ictal-interictal continuum in their EEGs. Abnormal muscle tonus (p = 0.034) and eye deviation (p = 0.021) were Significantly associated with a 2HELPS2B score ≥ 2. The presence of these manifestations (p < 0.001) and a 2HELPS2B score ≥ 2 (p < 0.001) were both significantly associated with a favorable response to anti-seizure medication. Conversely, patients with a 2HELPS2B score ≥ 2 who exhibited these clinical manifestations were more likely to be non-dischargeable (p = 0.053), have prolonged intensive care unit stays (p = 0.002), or require extended ventilator use (p = 0.082).  Conclusion  Abnormal muscle tonus and eye deviation were significant manifestations compatible with a 2HELPS2B score ≥ 2 and may indicate an increased risk of seizures or the severity of the epileptic condition.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186901218":{"attribute_name":"Funding Reference","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K16601","subitem_award_uri":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K16601/"},"subitem_award_titles":[{"subitem_award_title":"てんかん焦点切除術後の脳機能温存への生態信号限界値：広帯域皮質脳波での探索","subitem_award_title_language":"ja"}],"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"}]},{"subitem_award_titles":[{"subitem_award_title":"Intrinsic brain activities to predict post-operative brain function: wide-band electrocorticographic study"}],"subitem_funder_names":[{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"123174"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-08-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"123174","bibliographicVolumeNumber":"465","bibliographic_titles":[{"bibliographic_title":"Journal of the Neurological Sciences","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jns.2024.123174","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-08-10"}],"displaytype":"simple","fileDate":[{"fileDateType":"Available","fileDateValue":"2025-08-10"}],"filename":"JNS_465_123174.pdf","filesize":[{"value":"3.9 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007594/files/JNS_465_123174.pdf"},"version_id":"62c6aa48-da9a-4cfb-b4ed-8bf9fb98308f"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"55880"},"item_1732772494514":{"attribute_name":"備考","attribute_value":"The full-text file will be made open to the public on 10 August 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving'"},"item_title":"Clinical manifestations and outcomes associated with a high 2HELPS2B score in patients with acute impaired consciousness","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-12-18"},"publish_date":"2024-12-18","publish_status":"0","recid":"2007594","relation_version_is_last":true,"title":["Clinical manifestations and outcomes associated with a high 2HELPS2B score in patients with acute impaired consciousness"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T10:15:15.933181+00:00"}