| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function |
|
言語 |
en |
| 作成者 |
Patanasethanont, Denpong
Nagai, Junya
Yumoto, Ryoko
Murakami, Teruo
Sutthanut, Khaetthareeya
Sripanidkulchai, Bung-Orn
Yenjai, Chavi
Takano, Mikihisa
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2006 John Wiley & Sons, Inc. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Multidrug resistance |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
P-glycoprotein |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Cancer chemotherapy |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Bioavailability |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Cell culture |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
The purpose of this study was to examine the effects of extracts and flavone derivatives from the rhizome of Kaempferia parviflora on P-glycoprotein (P-gp)-mediated transport in LLC-GA5-COL150, a transfectant cell line of a porcine kidney epithelial cell line LLC-PK1 with human MDR1 cDNA. Ethanol extract obtained from Kaempferia parviflora rhizome significantly increased the accumulation of rhodamine 123 and daunorubicin, P-gp substrates, in LLC-GA5-COL150 cells, but not in LLC-PK1 cells. The aqueous extract also increased the accumulation in LLC-GA5-COL150 cells with lower potency than the ethanol extract. The effects of flavone derivatives isolated from the rhizome of Kaempferia parviflora on P-gp function were examined. Among six flavones tested, 3,5,7,3',4'-pentamethoxyflavone most potently increased the accumulation of rhodamine 123 and daunorubicin in LLC-GA5-COL150 cells in a concentration-dependent manner. In addition, 5,7-dimethoxyflavone to lesser degree increased rhodamine 123 accumulation in LLC-GA5-COL150 cells. In contrast, the other four flavone derivatives had no significant effect on the accumulation of rhodamine 123 in LLC-GA5-COL150 cells in a concentration range tested. These results indicate that extracts and flavone derivatives from the rhizome of Kaempferia parviflora can inhibit P-gp function, which may be useful for overcoming P-gp-mediated multidrug resistance and improving the oral bioavailability of anticancer agents. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
John Wiley & Sons Inc |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1002/jps.20769 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
17031860 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1002/jps.20769 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0022-3549 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00704450 |
| 開始ページ |
|
|
開始ページ |
223 |
| 書誌情報 |
Journal of Pharmaceutical Sciences
Journal of Pharmaceutical Sciences
巻 96,
号 1,
p. 223-233,
発行日 2006
|
| 旧ID |
20765 |
JPharmSci_96-1_223.pdf (496.4 KB)
