{"created":"2025-02-21T03:52:47.181510+00:00","id":2007464,"links":{},"metadata":{"_buckets":{"deposit":"e803b6af-8ed9-4486-b2a8-7a241c4ab20e"},"_deposit":{"created_by":41,"id":"2007464","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007464"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007464","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Patanasethanont, Denpong","creatorNameLang":"en"}],"familyNames":[{"familyName":"Patanasethanont","familyNameLang":"en"}],"givenNames":[{"givenName":"Denpong","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nagai, Junya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nagai","familyNameLang":"en"}],"givenNames":[{"givenName":"Junya","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yumoto, Ryoko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yumoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Ryoko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Murakami, Teruo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Murakami","familyNameLang":"en"}],"givenNames":[{"givenName":"Teruo","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sutthanut, Khaetthareeya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sutthanut","familyNameLang":"en"}],"givenNames":[{"givenName":"Khaetthareeya","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sripanidkulchai, Bung-Orn","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sripanidkulchai","familyNameLang":"en"}],"givenNames":[{"givenName":"Bung-Orn","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yenjai, Chavi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yenjai","familyNameLang":"en"}],"givenNames":[{"givenName":"Chavi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takano, Mikihisa","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takano","familyNameLang":"en"}],"givenNames":[{"givenName":"Mikihisa","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2006 John Wiley & Sons, Inc."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Multidrug resistance","subitem_subject_scheme":"Other"},{"subitem_subject":"P-glycoprotein","subitem_subject_scheme":"Other"},{"subitem_subject":"Cancer chemotherapy","subitem_subject_scheme":"Other"},{"subitem_subject":"Bioavailability","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell culture","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The purpose of this study was to examine the effects of extracts and flavone derivatives from the rhizome of Kaempferia parviflora on P-glycoprotein (P-gp)-mediated transport in LLC-GA5-COL150, a transfectant cell line of a porcine kidney epithelial cell line LLC-PK1 with human MDR1 cDNA. Ethanol extract obtained from Kaempferia parviflora rhizome significantly increased the accumulation of rhodamine 123 and daunorubicin, P-gp substrates, in LLC-GA5-COL150 cells, but not in LLC-PK1 cells. The aqueous extract also increased the accumulation in LLC-GA5-COL150 cells with lower potency than the ethanol extract. The effects of flavone derivatives isolated from the rhizome of Kaempferia parviflora on P-gp function were examined. Among six flavones tested, 3,5,7,3',4'-pentamethoxyflavone most potently increased the accumulation of rhodamine 123 and daunorubicin in LLC-GA5-COL150 cells in a concentration-dependent manner. In addition, 5,7-dimethoxyflavone to lesser degree increased rhodamine 123 accumulation in LLC-GA5-COL150 cells. In contrast, the other four flavone derivatives had no significant effect on the accumulation of rhodamine 123 in LLC-GA5-COL150 cells in a concentration range tested. These results indicate that extracts and flavone derivatives from the rhizome of Kaempferia parviflora can inhibit P-gp function, which may be useful for overcoming P-gp-mediated multidrug resistance and improving the oral bioavailability of anticancer agents.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons Inc"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0022-3549","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00704450","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"223"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"233","bibliographicPageStart":"223","bibliographicVolumeNumber":"96","bibliographic_titles":[{"bibliographic_title":"Journal of Pharmaceutical Sciences"},{"bibliographic_title":"Journal of Pharmaceutical Sciences"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/jps.20769","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"17031860","subitem_relation_type_select":"PMID"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1002/jps.20769","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"JPharmSci_96-1_223.pdf","filesize":[{"value":"496.4 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007464/files/JPharmSci_96-1_223.pdf"},"version_id":"e4566ffb-ba01-4bc6-9eae-69fcb59254de"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"20765"},"item_title":"Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2007464","relation_version_is_last":true,"title":["Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T09:59:56.378467+00:00"}