| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children’s Study |
|
言語 |
en |
| 作成者 |
Tsuji, Mayumi
Koriyama, Chihaya
Ishihara, Yasuhiro
Yamamoto, Megumi
Yamamoto-Hanada, Kiwako
Kanatani, Kumiko
Bamai, Yu Ait
Onishi, Kazunari
Senju, Ayako
Araki, Shunsuke
Shibata, Eiji
Morokuma, Seiichi
Sanefuji, Masafumi
Kitazawa, Hiroshi
Saito, Mayako
Umezawa, Masakazu
Onoda, Atsuto
Kusuhara, Koichi
Tanaka, Rie
Kawamoto, Toshihiro
the Japan Environment & Children’s Study Group
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright © 2019 Mayumi Tsuji et al. This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
metal concentrations |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
specific IgE |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
pregnant women |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
maternal health |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
allergic sensitization |
| 内容記述 |
|
|
内容記述 |
Background: Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children. Methods: We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children’s Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second=third trimester. Concentrations of the metals Cd, Pb, Hg, Se, and Mn, as well as serum total and allergen-specific IgEs for egg white, house dust-mites (HDM), Japanese cedar pollen (JCP), animal dander, and moth, were measured. Allergen-specific IgE(s) were divided based on concentrations <0.35 or ≥0.35UA=mL, and the metal levels were divided into quartiles. Results: Multivariable logistic regression analysis showed that there was a significant negative correlation between HDM- and animal dander-specific IgEs and Hg and Mn concentrations. Conversely, there was a significant positive relationship between JCP-specific IgE and Hg and Se concentrations. Conclusions: Metal exposures may be related to both increases and decreases in allergen-specific IgEs in pregnant women. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported by the Ministry of the Environment, Japan. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Supplementary data related to this article can be found at https://doi.org/10.2188/jea.JE20180098. |
| 出版者 |
|
|
出版者 |
Japan Epidemiological Association |
| 出版者 |
|
|
出版者 |
日本疫学会 |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.2188/jea.JE20180098 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
30643099 |
| 関連情報 |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2188/jea.JE20180098 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1349-9092 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0917-5040 |
| 開始ページ |
|
|
開始ページ |
478 |
| 書誌情報 |
Journal of Epidemiology
Journal of Epidemiology
巻 29,
号 12,
p. 478-486,
発行日 2019-12-05
|
| 旧ID |
48685 |
JEpidemiol_29_478.pdf (945.4 KB)
