{"created":"2025-02-21T03:48:46.405150+00:00","id":2007332,"links":{},"metadata":{"_buckets":{"deposit":"33361433-9c2e-4327-bd9c-1367251d860b"},"_deposit":{"created_by":41,"id":"2007332","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007332"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007332","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children’s Study","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsuji, Mayumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tsuji","familyNameLang":"en"}],"givenNames":[{"givenName":"Mayumi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Koriyama, Chihaya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Koriyama","familyNameLang":"en"}],"givenNames":[{"givenName":"Chihaya","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishihara, Yasuhiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ishihara","familyNameLang":"en"}],"givenNames":[{"givenName":"Yasuhiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamamoto, Megumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Megumi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamamoto-Hanada, Kiwako","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamamoto-Hanada","familyNameLang":"en"}],"givenNames":[{"givenName":"Kiwako","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kanatani, 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Eiji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Shibata","familyNameLang":"en"}],"givenNames":[{"givenName":"Eiji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Morokuma, Seiichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Morokuma","familyNameLang":"en"}],"givenNames":[{"givenName":"Seiichi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sanefuji, Masafumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sanefuji","familyNameLang":"en"}],"givenNames":[{"givenName":"Masafumi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kitazawa, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kitazawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Saito, Mayako","creatorNameLang":"en"}],"familyNames":[{"familyName":"Saito","familyNameLang":"en"}],"givenNames":[{"givenName":"Mayako","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Umezawa, Masakazu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Umezawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Masakazu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Onoda, Atsuto","creatorNameLang":"en"}],"familyNames":[{"familyName":"Onoda","familyNameLang":"en"}],"givenNames":[{"givenName":"Atsuto","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kusuhara, Koichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kusuhara","familyNameLang":"en"}],"givenNames":[{"givenName":"Koichi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanaka, Rie","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tanaka","familyNameLang":"en"}],"givenNames":[{"givenName":"Rie","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kawamoto, Toshihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kawamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Toshihiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"the Japan Environment & Children’s Study Group","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright © 2019 Mayumi Tsuji et al. This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"metal concentrations","subitem_subject_scheme":"Other"},{"subitem_subject":"specific IgE","subitem_subject_scheme":"Other"},{"subitem_subject":"pregnant women","subitem_subject_scheme":"Other"},{"subitem_subject":"maternal health","subitem_subject_scheme":"Other"},{"subitem_subject":"allergic sensitization","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Background: Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children.  Methods: We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children’s Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second=third trimester. Concentrations of the metals Cd, Pb, Hg, Se, and Mn, as well as serum total and allergen-specific IgEs for egg white, house dust-mites (HDM), Japanese cedar pollen (JCP), animal dander, and moth, were measured. Allergen-specific IgE(s) were divided based on concentrations <0.35 or ≥0.35UA=mL, and the metal levels were divided into quartiles.  Results: Multivariable logistic regression analysis showed that there was a significant negative correlation between HDM- and animal dander-specific IgEs and Hg and Mn concentrations. Conversely, there was a significant positive relationship between JCP-specific IgE and Hg and Se concentrations.  Conclusions: Metal exposures may be related to both increases and decreases in allergen-specific IgEs in pregnant women.","subitem_description_language":"en"},{"subitem_description":"This work was supported by the Ministry of the Environment, Japan.","subitem_description_type":"Other"},{"subitem_description":"Supplementary data related to this article can be found at https://doi.org/10.2188/jea.JE20180098.","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Japan Epidemiological Association"},{"subitem_publisher":"日本疫学会"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1349-9092","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"0917-5040","subitem_source_identifier_type":"ISSN"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"478"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-12-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"486","bibliographicPageStart":"478","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Journal of Epidemiology"},{"bibliographic_title":"Journal of Epidemiology"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2188/jea.JE20180098","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"30643099","subitem_relation_type_select":"PMID"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2188/jea.JE20180098","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"JEpidemiol_29_478.pdf","filesize":[{"value":"945.4 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007332/files/JEpidemiol_29_478.pdf"},"version_id":"07ba62a5-9c77-4ff1-9d85-99ca790750a8"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"48685"},"item_title":"Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children’s Study","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2007332","relation_version_is_last":true,"title":["Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children’s Study"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T09:44:33.329108+00:00"}