| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2025-01-21 |
| タイトル |
|
|
タイトル |
Stimulation of nuclear receptor REV-ERBs alleviates monosodium iodoacetate-induced osteoarthritis pathology of mice and the induction of inflammatory molecules expression in primary cultured chondrocytes |
|
言語 |
en |
| 作成者 |
Hashizume, Hiroki
Motonari, Hatsune
Yamamoto, Kenta
Nakamura, Yoki
Hisaoka-Nakashima, Kazue
Morioka, Norimitsu
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is not the published version. Please cite only the published version. |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
REV-ERBs |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Chronic pain |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Chondrocyte |
| 主題 |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Osteoarthritis |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Lipopolysaccharide |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Monosodium iodoacetate |
| 内容記述 |
|
|
内容記述 |
Because inflammation in chondrocytes contributes to the induction of osteoarthritis (OA), regulation of their activity is essential. A previous study showed that stimulation of the reverse erythroblastosis virus (REV-ERB) nuclear receptors in spinal glial cells elicits anti-inflammatory and antinociception effects in animal models of chronic pain. However, the involvement of REV-ERBs in chondrocyte functions and OA pathologies remains to be elucidated. In the current study, we found that pretreatment with the REV-ERB agonist SR9009 significantly blocked the increases in inflammatory molecules [(matrix metalloproteinase (MMP) 3, MMP9, and MMP13] and cytokines (interleukin-1β and tumor necrosis factor) in primary cultured chondrocytes following treatment with lipopolysaccharide. Furthermore, repeated intra-articular treatment with SR9009 significantly prevented monosodium iodoacetate-induced mechanical hypersensitivity and tended to partially reduce knee joint damage in mice. In conclusion, our findings suggest that REV-ERBs have a critical role in alleviating nociceptive hypersensitivity in OA pathologies by negatively regulating inflammation in chondrocytes. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported by grants from the Takeda Science Foundation, Suzuken Memorial Foundation, Uehara Memorial Foundation, and Nakatomi Foundation. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.intimp.2023.111349 |
| 開始ページ |
|
|
開始ページ |
111349 |
| 書誌情報 |
en : International Immunopharmacology
巻 127,
p. 111349,
発行日 2023-12-11
|
| 旧ID |
56143 |
IntImmpharm_127_111349.pdf (546.1 KB)
