{"created":"2025-02-21T03:40:42.206025+00:00","id":2007080,"links":{},"metadata":{"_buckets":{"deposit":"61c97a77-3495-401c-90a5-727dcf1607ab"},"_deposit":{"created_by":41,"id":"2007080","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007080"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007080","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Stimulation of nuclear receptor REV-ERBs alleviates monosodium iodoacetate-induced osteoarthritis pathology of mice and the induction of inflammatory molecules expression in primary cultured chondrocytes","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hashizume, Hiroki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hashizume","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Motonari, Hatsune","creatorNameLang":"en"}],"familyNames":[{"familyName":"Motonari","familyNameLang":"en"}],"givenNames":[{"givenName":"Hatsune","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamamoto, Kenta","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Kenta","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakamura, Yoki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nakamura","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hisaoka-Nakashima, Kazue","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hisaoka-Nakashima","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazue","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Morioka, Norimitsu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Morioka","familyNameLang":"en"}],"givenNames":[{"givenName":"Norimitsu","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"},{"subitem_rights":"This is not the published version. Please cite only the published version.","subitem_rights_language":"en"},{"subitem_rights":"この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。","subitem_rights_language":"ja"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"REV-ERBs","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chronic pain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chondrocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoarthritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipopolysaccharide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Monosodium iodoacetate","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Because inflammation in chondrocytes contributes to the induction of osteoarthritis (OA), regulation of their activity is essential. A previous study showed that stimulation of the reverse erythroblastosis virus (REV-ERB) nuclear receptors in spinal glial cells elicits anti-inflammatory and antinociception effects in animal models of chronic pain. However, the involvement of REV-ERBs in chondrocyte functions and OA pathologies remains to be elucidated. In the current study, we found that pretreatment with the REV-ERB agonist SR9009 significantly blocked the increases in inflammatory molecules [(matrix metalloproteinase (MMP) 3, MMP9, and MMP13] and cytokines (interleukin-1β and tumor necrosis factor) in primary cultured chondrocytes following treatment with lipopolysaccharide. Furthermore, repeated intra-articular treatment with SR9009 significantly prevented monosodium iodoacetate-induced mechanical hypersensitivity and tended to partially reduce knee joint damage in mice. In conclusion, our findings suggest that REV-ERBs have a critical role in alleviating nociceptive hypersensitivity in OA pathologies by negatively regulating inflammation in chondrocytes.","subitem_description_language":"en"},{"subitem_description":"This work was supported by grants from the Takeda Science Foundation, Suzuken Memorial Foundation, Uehara Memorial Foundation, and Nakatomi Foundation. ","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"111349"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-12-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"111349","bibliographicVolumeNumber":"127","bibliographic_titles":[{"bibliographic_title":"International Immunopharmacology","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.intimp.2023.111349","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-01-21"}],"displaytype":"simple","filename":"IntImmpharm_127_111349.pdf","filesize":[{"value":"546.1 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007080/files/IntImmpharm_127_111349.pdf"},"version_id":"f263b739-f933-4cce-9bc2-13dd8fc71342"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"56143"},"item_title":"Stimulation of nuclear receptor REV-ERBs alleviates monosodium iodoacetate-induced osteoarthritis pathology of mice and the induction of inflammatory molecules expression in primary cultured chondrocytes","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-01-21"},"publish_date":"2025-01-21","publish_status":"0","recid":"2007080","relation_version_is_last":true,"title":["Stimulation of nuclear receptor REV-ERBs alleviates monosodium iodoacetate-induced osteoarthritis pathology of mice and the induction of inflammatory molecules expression in primary cultured chondrocytes"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T09:05:15.824492+00:00"}