| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Immunoexpression of CXC-chemokine and recruitment of polymorphonuclear leukocytes in the rat molar periodontal tissue after topical application of lipopolysaccharide |
|
言語 |
en |
| 作成者 |
Miyauchi, Mutsumi
Kitagawa, Shoji
Hiraoka, Masae
Saito, Akihisa
Sato, Sunao
Kudo, Yasusei
Ogawa, Ikuko
Takata, Takashi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2004 Springer-Verlag. "The original publication is available at www.springerlink.com" |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Chemokine |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Lipopolysaccharide |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Polymorphonuclear leukocyte |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Periodontitis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Animal study |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Accumulating evidence indicates that an important event in the tissue response in periodontal disease is the recruitment of polymorphonuclear leukocytes (PMN). This study investigated immunohistochemical expression of CXC-chemokines, including macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant-2 (CINC-2) in rat periodontal tissue at 1 and 3 hours and 1, 2, 3 and 7 days after topical application of lipopolysaccharide (LPS; 5 mg/ml in saline) from E. Coli into the rat molar gingival sulcus. In normal periodontal tissues before LPS application, a small number of MIP-2 and CINC-2 positive cells were seen in junctional epithelium (JE) especially in its coronal half. After topical application of LPS, a prominent increase of MIP-2 and CINC-2 positive JE cells was observed. Almost all JE cells strongly expressed them at day 1 and day 2, and then the number of chemokine-positive cells returned to normal at day 7. Corresponding to these chemokine expressions, LPS application induced a significant increase in number of PMNs in sub-JE area at 1 hour (P <0.01) and 3 hours (P <0.05) and a significant increase in JE area at 1 day(P< 0.05) and 2 days (P <0.01), indicating a dynamic flow of PMNs from the sub-JE area into JE. These findings indicated that JE cells produced MIP-2 and CINC-2 in response to LPS stimulation and suggested that MIP-2 and CINC-2 may be responsible for PMN migration toward the periodontal pathogen and may play an important role in the initiation of inflammation and subsequent periodontal tissue destruction. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Springer |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s00418-004-0636-6 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1007/s00418-004-0636-6 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0948-6143 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11033302 |
| 開始ページ |
|
|
開始ページ |
291 |
| 書誌情報 |
Histochemistry and Cell Biology
Histochemistry and Cell Biology
巻 121,
号 4,
p. 291-297,
発行日 2004-03-24
|
| 旧ID |
21531 |
HistochemCellBiol_121_291.pdf (1.0 MB)
