{"created":"2025-02-21T03:37:47.380546+00:00","id":2006983,"links":{},"metadata":{"_buckets":{"deposit":"5c3bf29c-584e-4ec4-9a38-fee8cf4e06af"},"_deposit":{"created_by":41,"id":"2006983","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006983"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006983","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Immunoexpression of CXC-chemokine and recruitment of polymorphonuclear leukocytes in the rat molar periodontal tissue after topical application of lipopolysaccharide","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyauchi, Mutsumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Miyauchi","familyNameLang":"en"}],"givenNames":[{"givenName":"Mutsumi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kitagawa, Shoji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kitagawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Shoji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hiraoka, Masae","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hiraoka","familyNameLang":"en"}],"givenNames":[{"givenName":"Masae","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Saito, Akihisa","creatorNameLang":"en"}],"familyNames":[{"familyName":"Saito","familyNameLang":"en"}],"givenNames":[{"givenName":"Akihisa","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sato, Sunao","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sato","familyNameLang":"en"}],"givenNames":[{"givenName":"Sunao","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kudo, Yasusei","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kudo","familyNameLang":"en"}],"givenNames":[{"givenName":"Yasusei","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ogawa, Ikuko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ogawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Ikuko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takata, Takashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takata","familyNameLang":"en"}],"givenNames":[{"givenName":"Takashi","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2004 Springer-Verlag. \"The original publication is available at www.springerlink.com\""}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Chemokine","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipopolysaccharide","subitem_subject_scheme":"Other"},{"subitem_subject":"Polymorphonuclear leukocyte","subitem_subject_scheme":"Other"},{"subitem_subject":"Periodontitis","subitem_subject_scheme":"Other"},{"subitem_subject":"Animal study","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Accumulating evidence indicates that an important event in the tissue response in periodontal disease is the recruitment of polymorphonuclear leukocytes (PMN). This study investigated immunohistochemical expression of CXC-chemokines, including macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant-2 (CINC-2) in rat periodontal tissue at 1 and 3 hours and 1, 2, 3 and 7 days after topical application of lipopolysaccharide (LPS; 5 mg/ml in saline) from E. Coli into the rat molar gingival sulcus. In normal periodontal tissues before LPS application, a small number of MIP-2 and CINC-2 positive cells were seen in junctional epithelium (JE) especially in its coronal half. After topical application of LPS, a prominent increase of MIP-2 and CINC-2 positive JE cells was observed. Almost all JE cells strongly expressed them at day 1 and day 2, and then the number of chemokine-positive cells returned to normal at day 7. Corresponding to these chemokine expressions, LPS application induced a significant increase in number of PMNs in sub-JE area at 1 hour (P <0.01) and 3 hours (P <0.05) and a significant increase in JE area at 1 day(P< 0.05) and 2 days (P <0.01), indicating a dynamic flow of PMNs from the sub-JE area into JE.    These findings indicated that JE cells produced MIP-2 and CINC-2 in response to LPS stimulation and suggested that MIP-2 and CINC-2 may be responsible for PMN migration toward the periodontal pathogen and may play an important role in the initiation of inflammation and subsequent periodontal tissue destruction.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Springer"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0948-6143","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11033302","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"291"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-03-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"297","bibliographicPageStart":"291","bibliographicVolumeNumber":"121","bibliographic_titles":[{"bibliographic_title":"Histochemistry and Cell Biology"},{"bibliographic_title":"Histochemistry and Cell Biology"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00418-004-0636-6","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1007/s00418-004-0636-6","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"HistochemCellBiol_121_291.pdf","filesize":[{"value":"1.0 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006983/files/HistochemCellBiol_121_291.pdf"},"version_id":"8afeb57d-fcd9-46c8-aaf2-f22363055294"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"21531"},"item_title":"Immunoexpression of CXC-chemokine and recruitment of polymorphonuclear leukocytes in the rat molar periodontal tissue after topical application of lipopolysaccharide","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2006983","relation_version_is_last":true,"title":["Immunoexpression of CXC-chemokine and recruitment of polymorphonuclear leukocytes in the rat molar periodontal tissue after topical application of lipopolysaccharide"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T08:53:35.043313+00:00"}