| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Voltage-dependent calcium channel abnormalities in Hippocampal CA3 neurons of spontaneously epileptic rats |
|
言語 |
en |
| 作成者 |
Yan, Hai-Dun
Ishihara, Kumatoshi
Hanaya, Ryosuke
Kurisu, Kaoru
Serikawa, Tadao
Sasa, Masashi
|
| アクセス権 |
|
|
アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
権利情報 |
Copyright (c) 2007 Blackwell Publishing. The definitive version is available at www.blackwell-synergy.com |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Spontaneously epileptic rats (SER) |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Hippocampal CA3 neuron |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
Voltage-dependent Ca2+ channel (VDCCs) |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Ca2+ current |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
Patch-clamp |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
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|
内容記述 |
Purpose: Hippocampal CA3 neurons of spontaneously epileptic rats (SER; zi/zi, tm/tm), which show both absence-like seizures and tonic convulsions, exhibit a long-lasting depolarization shift with repetitive firing by a single stimulation of mossy fibers. Therefore, a whole cell patch clamp study using acutely dissociated hippocampal CA3 neurons from SER was performed to elucidate whether or not such abnormal excitability was due to abnormalities in voltage-dependent Ca2+ channels (VDCCs). Methods: Hippocampal CA3 neurons were acutely dissociated with enzymatic and mechanical treatments. In a voltage-clamp mode with whole-cell recording, depolarizing step pulses were applied to induce Ca2+ currents in the presence of tetrodotoxin and tetraethylammonium. Results: The threshold level of the Ca2+ current induced by depolarizing pulses was found to be lower in hippocampal CA3 neurons of SER compared with that of control Wistar rats. In addition, the Ca2+ current peak amplitude was greater, and decay of the current was weaker in CA3 neurons of SER than those of normal Wistar rats. Conclusion: These findings suggest that enhancements of Ca2+ influx into hippocampal CA3 neurons due to the easier activation properties of VDCCs, as well as a decrease in decay, are involved in SER epileptic seizures. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Blackwell Publishing |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1111/j.1528-1167.2007.00957.x |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1111/j.1528-1167.2007.00957.x |
| 収録物識別子 |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0013-9580 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00180597 |
| 開始ページ |
|
|
開始ページ |
758 |
| 書誌情報 |
Epilepsia
Epilepsia
巻 48,
号 4,
p. 758-764,
発行日 2007-04
|
| 旧ID |
20593 |
Epilepsia_48-4_758.pdf (216.5 KB)
