{"created":"2025-02-21T03:33:08.160250+00:00","id":2006826,"links":{},"metadata":{"_buckets":{"deposit":"715f2008-3282-4909-a05c-9c87af9ef439"},"_deposit":{"created_by":41,"id":"2006826","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006826"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006826","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Voltage-dependent calcium channel abnormalities in Hippocampal CA3 neurons of spontaneously epileptic rats","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yan, Hai-Dun","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yan","familyNameLang":"en"}],"givenNames":[{"givenName":"Hai-Dun","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishihara, Kumatoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ishihara","familyNameLang":"en"}],"givenNames":[{"givenName":"Kumatoshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hanaya, Ryosuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hanaya","familyNameLang":"en"}],"givenNames":[{"givenName":"Ryosuke","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kurisu, Kaoru","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kurisu","familyNameLang":"en"}],"givenNames":[{"givenName":"Kaoru","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Serikawa, Tadao","creatorNameLang":"en"}],"familyNames":[{"familyName":"Serikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Tadao","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sasa, Masashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sasa","familyNameLang":"en"}],"givenNames":[{"givenName":"Masashi","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2007 Blackwell Publishing. The definitive version is available at www.blackwell-synergy.com"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Spontaneously epileptic rats (SER)","subitem_subject_scheme":"Other"},{"subitem_subject":"Hippocampal CA3 neuron","subitem_subject_scheme":"Other"},{"subitem_subject":"Voltage-dependent Ca2+ channel (VDCCs)","subitem_subject_scheme":"Other"},{"subitem_subject":"Ca2+ current","subitem_subject_scheme":"Other"},{"subitem_subject":"Patch-clamp","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Purpose: Hippocampal CA3 neurons of spontaneously epileptic rats (SER; zi/zi, tm/tm), which show both absence-like seizures and tonic convulsions, exhibit a long-lasting depolarization shift with repetitive firing by a single stimulation of mossy fibers. Therefore, a whole cell patch clamp study using acutely dissociated hippocampal CA3 neurons from SER was performed to elucidate whether or not such abnormal excitability was due to abnormalities in voltage-dependent Ca2+ channels (VDCCs). Methods: Hippocampal CA3 neurons were acutely dissociated with enzymatic and mechanical treatments. In a voltage-clamp mode with whole-cell recording, depolarizing step pulses were applied to induce Ca2+ currents in the presence of tetrodotoxin and tetraethylammonium. Results: The threshold level of the Ca2+ current induced by depolarizing pulses was found to be lower in hippocampal CA3 neurons of SER compared with that of control Wistar rats. In addition, the Ca2+ current peak amplitude was greater, and decay of the current was weaker in CA3 neurons of SER than those of normal Wistar rats. Conclusion: These findings suggest that enhancements of Ca2+ influx into hippocampal CA3 neurons due to the easier activation properties of VDCCs, as well as a decrease in decay, are involved in SER epileptic seizures.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Blackwell Publishing"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0013-9580","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00180597","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"758"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"764","bibliographicPageStart":"758","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"Epilepsia"},{"bibliographic_title":"Epilepsia"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.1528-1167.2007.00957.x","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1111/j.1528-1167.2007.00957.x","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"Epilepsia_48-4_758.pdf","filesize":[{"value":"216.5 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006826/files/Epilepsia_48-4_758.pdf"},"version_id":"4f95e7ac-e4e9-4d77-a568-31956c4b4be9"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"20593"},"item_title":"Voltage-dependent calcium channel abnormalities in Hippocampal CA3 neurons of spontaneously epileptic rats","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2006826","relation_version_is_last":true,"title":["Voltage-dependent calcium channel abnormalities in Hippocampal CA3 neurons of spontaneously epileptic rats"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T08:30:54.700874+00:00"}