| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae |
|
言語 |
en |
| 作成者 |
Yokoyama, Hiroshi
Mizunuma, Masaki
Okamoto, Michiyo
Yamamoto, Josuke
Hirata, Dai
Miyakawa, Tokichi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2006 European Molecular Biology Organization |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
calcium |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
calcineurin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Swe1p |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Yap1p |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
yeast |
| 内容記述 |
|
|
内容記述 |
The Ca2+-activated pathways in Saccharomyces cerevisiae induce a delay in the onset of mitosis through the activation of Swe1p, a negative regulatory kinase that inhibits the Cdc28p/Clb complex. We isolated the YAP1 gene as a multicopy suppressor of calcium sensitivity owing to the loss of ZDS1, a negative regulator of SWE1 and CLN2 gene expression. YAP1 deletion on a zds1Δ background exacerbated the Ca2+-related phenotype. Yap1p was degraded in a calcineurin-dependent manner when cells were exposed to calcium. In yap1Δ cells, the expression level of the RPN4 gene encoding a transcription factor for the subunits of the ubiquitin - proteasome system was diminished. The deletion of YAP1 gene or RPN4 gene led to the accumulation of Swe1p and Cln2p. Yap1p was a substrate of calcineurin in vivo and in vitro. The calcineurin-mediated Yap1p degradation seems to be a long adaptive response that assures a G2 delay in response to a stress that causes the activation of the calcium signalling pathways. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Nature Publishing Group |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1038/sj.embor.7400647 |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1038/sj.embor.7400647 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1469-221X |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11472481 |
| 開始ページ |
|
|
開始ページ |
519 |
| 書誌情報 |
EMBO Reports
EMBO Reports
巻 7,
号 5,
p. 519-524,
発行日 2006-05
|
| 旧ID |
15064 |
EMBOrep_7_519.pdf (1.8 MB)
