{"created":"2025-02-21T03:31:37.263693+00:00","id":2006774,"links":{},"metadata":{"_buckets":{"deposit":"995bf57c-210b-49a1-991a-5719a430fa89"},"_deposit":{"created_by":41,"id":"2006774","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006774"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006774","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yokoyama, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yokoyama","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mizunuma, Masaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Mizunuma","familyNameLang":"en"}],"givenNames":[{"givenName":"Masaki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okamoto, Michiyo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Okamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Michiyo","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamamoto, Josuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Josuke","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hirata, Dai","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hirata","familyNameLang":"en"}],"givenNames":[{"givenName":"Dai","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miyakawa, Tokichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Miyakawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Tokichi","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2006 European Molecular Biology Organization"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"calcium","subitem_subject_scheme":"Other"},{"subitem_subject":"calcineurin","subitem_subject_scheme":"Other"},{"subitem_subject":"Swe1p","subitem_subject_scheme":"Other"},{"subitem_subject":"Yap1p","subitem_subject_scheme":"Other"},{"subitem_subject":"yeast","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The Ca2+-activated pathways in Saccharomyces cerevisiae induce a delay in the onset of mitosis through the activation of Swe1p, a negative regulatory kinase that inhibits the Cdc28p/Clb complex. We isolated the YAP1 gene as a multicopy suppressor of calcium sensitivity owing to the loss of ZDS1, a negative regulator of SWE1 and CLN2 gene expression. YAP1 deletion on a zds1Δ background exacerbated the Ca2+-related phenotype. Yap1p was degraded in a calcineurin-dependent manner when cells were exposed to calcium. In yap1Δ cells, the expression level of the RPN4 gene encoding a transcription factor for the subunits of the ubiquitin - proteasome system was diminished. The deletion of YAP1 gene or RPN4 gene led to the accumulation of Swe1p and Cln2p. Yap1p was a substrate of calcineurin in vivo and in vitro. The calcineurin-mediated Yap1p degradation seems to be a long adaptive response that assures a G2 delay in response to a stress that causes the activation of the calcium signalling pathways.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1469-221X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11472481","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"519"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"524","bibliographicPageStart":"519","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"EMBO Reports"},{"bibliographic_title":"EMBO Reports"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/sj.embor.7400647","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1038/sj.embor.7400647","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"EMBOrep_7_519.pdf","filesize":[{"value":"1.8 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006774/files/EMBOrep_7_519.pdf"},"version_id":"9911dcb8-dcb3-4216-8404-f69eb0ecad47"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"15064"},"item_title":"Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2006774","relation_version_is_last":true,"title":["Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T08:25:49.106394+00:00"}