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Atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-alpha-lowering property

https://hiroshima.repo.nii.ac.jp/records/2006745
https://hiroshima.repo.nii.ac.jp/records/2006745
ec4cf6f8-d901-4047-b4cd-e25a911c766a
名前 / ファイル ライセンス アクション
DLD_44_492.pdf DLD_44_492.pdf (666.8 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-alpha-lowering property
言語 en
作成者 Hyogo, Hideyuki

× Hyogo, Hideyuki

en Hyogo, Hideyuki

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Yamagishi, Shoichi

× Yamagishi, Shoichi

en Yamagishi, Shoichi

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Maeda, Sayaka

× Maeda, Sayaka

en Maeda, Sayaka

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Kimura, Yuki

× Kimura, Yuki

en Kimura, Yuki

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Ishitobi, Tomokazu

× Ishitobi, Tomokazu

en Ishitobi, Tomokazu

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Chayama, Kazuaki

× Chayama, Kazuaki

en Chayama, Kazuaki

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 (c) 2011 Elsevier Inc. All rights reserved.
主題
主題Scheme Other
主題 Atorvastatin
主題
主題Scheme Other
主題 Inflammation
主題
主題Scheme Other
主題 NASH
主題
主題Scheme Other
主題 TNF-alpha
主題
主題Scheme NDC
主題 490
内容記述
内容記述 Background: We have previously found that atorvastatin decreases liver injury markers in patients with nonalcoholic steatohepatitis. However, how atorvastatin treatment ameliorates the disease activity in nonalcoholic steatohepatitis patients remains unknown. Aims: We examined here which anthropometric, metabolic and inflammatory variables were improved and related with amelioration of disease activity in atorvastatin-treated nonalcoholic steatohepatitis patients. Methods: Forty-two biopsy-proven nonalcoholic steatohepatitis patients with dyslipidemia were enrolled. Patients were treated with atorvastatin (10 mg/day) for 12 months. Results: Atorvastatin significantly decreased liver transaminase, gamma-glutamyl transpeptidase, low-density lipoprotein-cholesterol, triglycerides, type IV collagen, and tumour necrosis factor-alpha levels, whilst it increased adiponectin and high-density lipoprotein-cholesterol. Atorvastatin improved nonalcoholic fatty liver disease activity score and increased liver to spleen density ratio. Multiple stepwise regression analysis revealed that gamma-glutamyl transpeptidase, tumour necrosis factor-alpha and liver to spleen density ratio ( inversely) were independently associated with nonalcoholic fatty liver disease activity score. Aspartate aminotransferase, low-density lipoprotein-cholesterol and nonalcoholic fatty liver disease activity score were independent determinants of decreased liver to spleen density ratio. Conclusion: The present study suggests that atorvastatin improves the disease activity of nonalcoholic steatohepatitis partly via its tumour necrosis factor-alpha-lowering property. (C) 2011 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
言語 en
出版者
出版者 Elsevier Science INC
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ AO
出版タイプResource http://purl.org/coar/version/c_b1a7d7d4d402bcce
関連情報
識別子タイプ DOI
関連識別子 10.1016/j.dld.2011.12.013
関連情報
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1016/j.dld.2011.12.013
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1590-8658
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA11610665
開始ページ
開始ページ 492
書誌情報 Digestive and Liver Disease
Digestive and Liver Disease

巻 44, 号 6, p. 492-496, 発行日 2012
旧ID 34830
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