Item type |
デフォルトアイテムタイプ_(フル)(1) |
公開日 |
2023-03-18 |
タイトル |
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タイトル |
Atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-alpha-lowering property |
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言語 |
en |
作成者 |
Hyogo, Hideyuki
Yamagishi, Shoichi
Maeda, Sayaka
Kimura, Yuki
Ishitobi, Tomokazu
Chayama, Kazuaki
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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権利情報 |
(c) 2011 Elsevier Inc. All rights reserved. |
主題 |
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主題Scheme |
Other |
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主題 |
Atorvastatin |
主題 |
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主題Scheme |
Other |
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主題 |
Inflammation |
主題 |
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主題Scheme |
Other |
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主題 |
NASH |
主題 |
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主題Scheme |
Other |
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主題 |
TNF-alpha |
主題 |
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主題Scheme |
NDC |
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主題 |
490 |
内容記述 |
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内容記述 |
Background: We have previously found that atorvastatin decreases liver injury markers in patients with nonalcoholic steatohepatitis. However, how atorvastatin treatment ameliorates the disease activity in nonalcoholic steatohepatitis patients remains unknown. Aims: We examined here which anthropometric, metabolic and inflammatory variables were improved and related with amelioration of disease activity in atorvastatin-treated nonalcoholic steatohepatitis patients. Methods: Forty-two biopsy-proven nonalcoholic steatohepatitis patients with dyslipidemia were enrolled. Patients were treated with atorvastatin (10 mg/day) for 12 months. Results: Atorvastatin significantly decreased liver transaminase, gamma-glutamyl transpeptidase, low-density lipoprotein-cholesterol, triglycerides, type IV collagen, and tumour necrosis factor-alpha levels, whilst it increased adiponectin and high-density lipoprotein-cholesterol. Atorvastatin improved nonalcoholic fatty liver disease activity score and increased liver to spleen density ratio. Multiple stepwise regression analysis revealed that gamma-glutamyl transpeptidase, tumour necrosis factor-alpha and liver to spleen density ratio ( inversely) were independently associated with nonalcoholic fatty liver disease activity score. Aspartate aminotransferase, low-density lipoprotein-cholesterol and nonalcoholic fatty liver disease activity score were independent determinants of decreased liver to spleen density ratio. Conclusion: The present study suggests that atorvastatin improves the disease activity of nonalcoholic steatohepatitis partly via its tumour necrosis factor-alpha-lowering property. (C) 2011 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. |
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言語 |
en |
出版者 |
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出版者 |
Elsevier Science INC |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
出版タイプ |
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出版タイプ |
AO |
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出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.dld.2011.12.013 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
http://dx.doi.org/10.1016/j.dld.2011.12.013 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1590-8658 |
収録物識別子 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11610665 |
開始ページ |
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開始ページ |
492 |
書誌情報 |
Digestive and Liver Disease
Digestive and Liver Disease
巻 44,
号 6,
p. 492-496,
発行日 2012
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旧ID |
34830 |