{"created":"2025-02-21T03:30:44.754176+00:00","id":2006745,"links":{},"metadata":{"_buckets":{"deposit":"e0714f15-e0d4-4e65-8a5a-70f8387ffd3f"},"_deposit":{"created_by":41,"id":"2006745","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006745"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006745","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-alpha-lowering property","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hyogo, Hideyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hyogo","familyNameLang":"en"}],"givenNames":[{"givenName":"Hideyuki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamagishi, Shoichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamagishi","familyNameLang":"en"}],"givenNames":[{"givenName":"Shoichi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Maeda, Sayaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"Maeda","familyNameLang":"en"}],"givenNames":[{"givenName":"Sayaka","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kimura, Yuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kimura","familyNameLang":"en"}],"givenNames":[{"givenName":"Yuki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishitobi, Tomokazu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ishitobi","familyNameLang":"en"}],"givenNames":[{"givenName":"Tomokazu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Chayama, Kazuaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Chayama","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazuaki","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"(c) 2011 Elsevier Inc. All rights reserved."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Atorvastatin","subitem_subject_scheme":"Other"},{"subitem_subject":"Inflammation","subitem_subject_scheme":"Other"},{"subitem_subject":"NASH","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF-alpha","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Background: We have previously found that atorvastatin decreases liver injury markers in patients with nonalcoholic steatohepatitis. However, how atorvastatin treatment ameliorates the disease activity in nonalcoholic steatohepatitis patients remains unknown.   Aims: We examined here which anthropometric, metabolic and inflammatory variables were improved and related with amelioration of disease activity in atorvastatin-treated nonalcoholic steatohepatitis patients.   Methods: Forty-two biopsy-proven nonalcoholic steatohepatitis patients with dyslipidemia were enrolled. Patients were treated with atorvastatin (10 mg/day) for 12 months.   Results: Atorvastatin significantly decreased liver transaminase, gamma-glutamyl transpeptidase, low-density lipoprotein-cholesterol, triglycerides, type IV collagen, and tumour necrosis factor-alpha levels, whilst it increased adiponectin and high-density lipoprotein-cholesterol. Atorvastatin improved nonalcoholic fatty liver disease activity score and increased liver to spleen density ratio. Multiple stepwise regression analysis revealed that gamma-glutamyl transpeptidase, tumour necrosis factor-alpha and liver to spleen density ratio ( inversely) were independently associated with nonalcoholic fatty liver disease activity score. Aspartate aminotransferase, low-density lipoprotein-cholesterol and nonalcoholic fatty liver disease activity score were independent determinants of decreased liver to spleen density ratio.   Conclusion: The present study suggests that atorvastatin improves the disease activity of nonalcoholic steatohepatitis partly via its tumour necrosis factor-alpha-lowering property. (C) 2011 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier Science INC"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1590-8658","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11610665","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"492"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"496","bibliographicPageStart":"492","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Digestive and Liver Disease"},{"bibliographic_title":"Digestive and Liver Disease"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.dld.2011.12.013","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.dld.2011.12.013","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"DLD_44_492.pdf","filesize":[{"value":"666.8 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006745/files/DLD_44_492.pdf"},"version_id":"f8858fff-a685-4968-9f70-f0d8770a1c37"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"34830"},"item_title":"Atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-alpha-lowering property","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2006745","relation_version_is_last":true,"title":["Atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-alpha-lowering property"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T08:19:43.658239+00:00"}