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Acid-suppressive effects of generic omeprazole: Comparison of three brands of generic omeprazole with original omeprazole
https://hiroshima.repo.nii.ac.jp/records/2006744
https://hiroshima.repo.nii.ac.jp/records/20067444229c661-9294-4ca0-9826-ad75c02ebedf
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DLD_38_554.pdf (290.6 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Acid-suppressive effects of generic omeprazole: Comparison of three brands of generic omeprazole with original omeprazole | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 作成者 |
Shimatani, Tomohiko
× Shimatani, Tomohiko
× Inoue, M.
× Kuroiwa, T.
× Xu, J.
× Mieno, H.
× Tazuma, S.
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| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Generic product | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Intragastric pH | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Omeprazole | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 主題Scheme | NDC | |||||||||||||||||
| 主題 | 490 | |||||||||||||||||
| 内容記述 | ||||||||||||||||||
| 内容記述 | Background: Generic omeprazole contains the same active ingredient as original omeprazole and require verification of the bioequivalence with original omeprazole. However, very few clinical studies have been reported. Aims: A prospective, randomised, open-label, crossover study to compare acid-suppressive effect of generic omeprazole with that of original omeprazole. Subjects: Seven healthy Helicobacter pylori-negative subjects of CYP2C19 extensive metaboliser. Methods: Intragastric pH was measured for 24 h without medications (placebo) and on day 7 of repeated administration of 10 mg once daily after breakfast of original omeprazole, Omeprazon, or three brands of generic omeprazole, Omeprazole-Towa, Ovulanze or Omerap. Results: Median values of intragastric pH and percentages of time with pH > 4 for 24 h were significantly higher with administration of any omeprazole formulation compared with placebo (P < 0.05, Wilcoxon signed-rank test). Whereas, during the night-time period (20:00-08:00 h), percentages of time with pH > 4 with Omeprazole-Towa and Omerap were not significantly higher than placebo. Compared with Omeprazon, these two parameters for 24 h showed significantly greater inter-subject variations with Omeprazole-Towa (P < 0.05 and P < 0.01, F-test) and Ovulanze (P < 0.05). Conclusions: Acid-suppressive effects of some brands of generic omeprazole are not the same as original omeprazole. These differences might be reflected in clinical outcomes. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | AO | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce | |||||||||||||||||
| 関連情報 | ||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | 10.1016/j.dld.2006.01.032 | |||||||||||||||||
| 関連情報 | ||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||
| 関連識別子 | 16524789 | |||||||||||||||||
| 関連情報 | ||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | http://dx.doi.org/10.1016/j.dld.2006.01.032 | |||||||||||||||||
| 収録物識別子 | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 1590-8658 | |||||||||||||||||
| 収録物識別子 | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA11610665 | |||||||||||||||||
| 開始ページ | ||||||||||||||||||
| 開始ページ | 554 | |||||||||||||||||
| 書誌情報 |
Digestive and Liver Disease Digestive and Liver Disease 巻 38, 号 8, p. 554-559, 発行日 2006-08 |
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| 旧ID | 15022 | |||||||||||||||||
