{"created":"2025-02-21T03:30:43.896901+00:00","id":2006744,"links":{},"metadata":{"_buckets":{"deposit":"059de0e6-00e2-4a65-b598-65890950437d"},"_deposit":{"created_by":41,"id":"2006744","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006744"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006744","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Acid-suppressive effects of generic omeprazole: Comparison of three brands of generic omeprazole with original omeprazole","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimatani, Tomohiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Shimatani","familyNameLang":"en"}],"givenNames":[{"givenName":"Tomohiko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Inoue, M.","creatorNameLang":"en"}],"familyNames":[{"familyName":"Inoue","familyNameLang":"en"}],"givenNames":[{"givenName":"M.","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kuroiwa, T.","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kuroiwa","familyNameLang":"en"}],"givenNames":[{"givenName":"T.","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Xu, J.","creatorNameLang":"en"}],"familyNames":[{"familyName":"Xu","familyNameLang":"en"}],"givenNames":[{"givenName":"J.","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mieno, H.","creatorNameLang":"en"}],"familyNames":[{"familyName":"Mieno","familyNameLang":"en"}],"givenNames":[{"givenName":"H.","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tazuma, S.","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tazuma","familyNameLang":"en"}],"givenNames":[{"givenName":"S.","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Generic product","subitem_subject_scheme":"Other"},{"subitem_subject":"Intragastric pH","subitem_subject_scheme":"Other"},{"subitem_subject":"Omeprazole","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Background: Generic omeprazole contains the same active ingredient as original omeprazole and require verification of the bioequivalence with original omeprazole. However, very few clinical studies have been reported. Aims: A prospective, randomised, open-label, crossover study to compare acid-suppressive effect of generic omeprazole with that of original omeprazole. Subjects: Seven healthy Helicobacter pylori-negative subjects of CYP2C19 extensive metaboliser. Methods: Intragastric pH was measured for 24 h without medications (placebo) and on day 7 of repeated administration of 10 mg once daily after breakfast of original omeprazole, Omeprazon, or three brands of generic omeprazole, Omeprazole-Towa, Ovulanze or Omerap. Results: Median values of intragastric pH and percentages of time with pH > 4 for 24 h were significantly higher with administration of any omeprazole formulation compared with placebo (P < 0.05, Wilcoxon signed-rank test). Whereas, during the night-time period (20:00-08:00 h), percentages of time with pH > 4 with Omeprazole-Towa and Omerap were not significantly higher than placebo. Compared with Omeprazon, these two parameters for 24 h showed significantly greater inter-subject variations with Omeprazole-Towa (P < 0.05 and P < 0.01, F-test) and Ovulanze (P < 0.05). Conclusions: Acid-suppressive effects of some brands of generic omeprazole are not the same as original omeprazole. These differences might be reflected in clinical outcomes.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1590-8658","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11610665","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"554"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"559","bibliographicPageStart":"554","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Digestive and Liver Disease"},{"bibliographic_title":"Digestive and Liver Disease"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.dld.2006.01.032","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"16524789","subitem_relation_type_select":"PMID"}},{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.dld.2006.01.032","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"DLD_38_554.pdf","filesize":[{"value":"290.6 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006744/files/DLD_38_554.pdf"},"version_id":"170a343d-4e3c-40a5-a83c-b0b5c0f775e6"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"15022"},"item_title":"Acid-suppressive effects of generic omeprazole: Comparison of three brands of generic omeprazole with original omeprazole","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2006744","relation_version_is_last":true,"title":["Acid-suppressive effects of generic omeprazole: Comparison of three brands of generic omeprazole with original omeprazole"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T08:19:37.750681+00:00"}