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Creation of highly functional CO_3Ap-collagen scaffold biomaterials
https://hiroshima.repo.nii.ac.jp/records/2006725
https://hiroshima.repo.nii.ac.jp/records/200672566c3fa35-1a88-4cfc-a550-6ba686fac103
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DentMaterJ_29_1.pdf (1.2 MB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Creation of highly functional CO_3Ap-collagen scaffold biomaterials | |||||||
| 言語 | en | |||||||
| 作成者 |
Okazaki, Masayuki
× Okazaki, Masayuki
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 権利情報 | ||||||||
| 権利情報 | Copyright (c) 2010 日本歯科理工学会 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Scaffold biomaterials | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | CO_3Ap-collagen | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | High function | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | Physicochemical properties of apatites are affected dramatically by the substitution of trace elements. Especially, biological apatites constituting bone and teeth contain several wt% of CO32– ions, which are related to the crystallinity and solubility. Recently, scaffold biomaterials are being developed with a shape-maintaining property in addition to large pores and high porosity, into which cells can easily invade. To develop a new biodegradable scaffold biomaterial, bone-like carbonate apatites (CO3Ap) were synthesized and CO3Ap–collagen scaffolds were created. This scaffold biomaterial is useful for regions with bone regeneration ability. When these sponge-frame complexes with rh-BMP2 were implanted beneath the periosteum cranii of rats, sufficient new bone was created at the surface of the periosteum cranii after 4 weeks' implantation. Furthermore, when a CO3Ap-collagen sponge containing SVVYGLR peptide was implanted as a graft into a tissue defect created in rat tibia, the migration of numerous vascular endothelial cells, as well as prominent angiogenesis inside the graft, could be detected after 1 week. Thus, the modification of higher functions such as cytokine and angiogenesis factors is effective for low regeneration regions using tissue engineering biomaterials. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | Japanese Society for Dental Materials and Devices | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.4012/dmj.2009-R01 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | http://dx.doi.org/10.4012/dmj.2009-R01 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://wwwsoc.nii.ac.jp/jsdmd/2010/all2010.html#top29-1 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0287-4547 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA10443149 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 1 | |||||||
| 書誌情報 |
Dental Materials Journal Dental Materials Journal 巻 29, 号 1, p. 1-3, 発行日 2010 |
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| 旧ID | 30403 | |||||||
