| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Physicochemical Cause and Effect Observed in DNA Length-Dependent Division of Protocell as the Primitive Flow of Information |
|
言語 |
en |
| 作成者 |
Matsuo, Muneyuki
Kurihara, Kensuke
Toyota, Taro
Suzuki, Kentaro
Sugawara, Tadashi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
© 2020 Matsuo M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Protocell |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Self-reproduction |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
DNA-chain length |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Primitive flow of information |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Physicochemical causes and effects |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Morphological change |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Lipo-deoxyribozyme |
| 内容記述 |
|
|
内容記述 |
In the prebiotic era, physicochemical cause and effect served as the primitive flow of information for protocells. Our recent study claimed that the manners and frequencies of self-reproduction of giant vesicle (GV) -based model protocells were regulated by the incorporated DNA-length, and not the base-pair sequence due to the presence of a supramolecular catalyst (lipo-deoxyribozyme) composed of DNA and lipophilic catalysts. The DNA-length dependent dynamics of the self-reproducing GVs containing different length of DNA were examined by three independent experiments; Population analysis by flow cytometric measurements, counting of increased numbers of protocells and direct morphological observation of a single GV by confocal microscopy. These results may shed light on the information system in the prebiotic stage, when the central dogma was not established. Notably, recent reports have revealed the possible influence of DNA length on the activation of living cells through the complexation of DNA to an enzyme in non-sequential aggregation manner. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported by JSPS KAKENHI (Grant Numbers JP25103009, JP16K05759 and JP17H04876), ‘Platform for Dynamic Approaches to Living System’ at the University of Tokyo, Kanagawa University Grant for Joint Research, and the Yoshida Scholarship Foundation. |
| 出版者 |
|
|
出版者 |
Longdom Publishing |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.35248/2471-2663.20.06.150 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.35248/2471-2663.20.06.150 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2471-2663 |
| 書誌情報 |
Clinical & Medical Biochemistry
Clinical & Medical Biochemistry
巻 6,
号 3,
発行日 2020-10-26
|
| 旧ID |
51564 |
ClinMedBiochem_Matsuo_2020.pdf (315.4 KB)
