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Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer

https://hiroshima.repo.nii.ac.jp/records/2006556
https://hiroshima.repo.nii.ac.jp/records/2006556
25f7decd-e712-45a6-8a4b-a449d13ae6ad
名前 / ファイル ライセンス アクション
CancerScience_98-8_1198.pdf CancerScience_98-8_1198.pdf (963.5 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer
言語 en
作成者 Oue, Naohide

× Oue, Naohide

en Oue, Naohide

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Yoshida, Kazuhiro

× Yoshida, Kazuhiro

en Yoshida, Kazuhiro

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Noguchi, Tsuyoshi

× Noguchi, Tsuyoshi

en Noguchi, Tsuyoshi

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Sentani, Kazuhiro

× Sentani, Kazuhiro

en Sentani, Kazuhiro

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Kikuchi, Akira

× Kikuchi, Akira

en Kikuchi, Akira

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Yasui, Wataru

× Yasui, Wataru

en Yasui, Wataru

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright (c) 2007 Blackwell Publishing. The definitive version is available at www.blackwell-synergy.com
主題
主題Scheme NDC
主題 490
内容記述
内容記述 The human homolog of the Drosophila prune protein (from PRUNE, which encodes h-prune), which interacts with glycogen synthase kinase 3, promotes cellular motility. H-prune also interacts with nm23-H1, a suppressor of cancer metastasis. It has been reported that stimulation of cellular motility by h-prune is enhanced by its interaction with nm23-H1 in breast cancer cells. In the present study, we examined the expression of h-prune and nm23-H1 during tumor progression in gastric cancer (GC). PRUNE mRNA was overexpressed in 12 (32%) of 38 GC cases by quantitative reverse transcription-polymerase chain reaction. PRUNE mRNA levels correlated significantly with advanced T grade, N grade and tumor stage. Immunohistochemical analysis revealed that 43 (30%) of 143 GC cases were positive for h-prune, and h-prune-positive GC cases showed more advanced T grade, N grade and tumor stage than h-prune-negative GC cases. One hundred and twenty-four (87%) of 143 GC cases were positive for nm23-H1, and nm23-H1 was expressed in almost all (42 cases, 98%) h-prune-positive GC cases. Many GC cases positive for both h-prune and nm23-H1 showed more advanced T grade, N grade and tumor stage than other type GC cases. Patients with h-prune-positive GC had a significantly worse survival rate than patients with h-prune-negative GC. These findings indicate that overexpression of h-prune is associated with tumor progression and aggressiveness of GC. nm23-H1 may enhance motility of cancer cells by interacting with h-prune. (Cancer Sci 2007; 98: 1198-1205)
言語 en
出版者
出版者 Blackwell Publishing
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ AO
出版タイプResource http://purl.org/coar/version/c_b1a7d7d4d402bcce
関連情報
識別子タイプ DOI
関連識別子 10.1111/j.1349-7006.2007.00515.x
関連情報
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1111/j.1349-7006.2007.00515.x
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1347-9032
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA11808050
開始ページ
開始ページ 1198
書誌情報 Cancer Science
Cancer Science

巻 98, 号 8, p. 1198-1205, 発行日 2007-08
旧ID 20725
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