{"created":"2025-02-21T03:24:55.150150+00:00","id":2006556,"links":{},"metadata":{"_buckets":{"deposit":"3ea96fc1-359d-4647-9061-ffbfaf53c735"},"_deposit":{"created_by":41,"id":"2006556","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006556"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006556","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oue, Naohide","creatorNameLang":"en"}],"familyNames":[{"familyName":"Oue","familyNameLang":"en"}],"givenNames":[{"givenName":"Naohide","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshida, Kazuhiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yoshida","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazuhiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Noguchi, Tsuyoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Noguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"Tsuyoshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sentani, Kazuhiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sentani","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazuhiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kikuchi, Akira","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kikuchi","familyNameLang":"en"}],"givenNames":[{"givenName":"Akira","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yasui, Wataru","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yasui","familyNameLang":"en"}],"givenNames":[{"givenName":"Wataru","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2007 Blackwell Publishing. The definitive version is available at www.blackwell-synergy.com"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The human homolog of the Drosophila prune protein (from PRUNE, which encodes h-prune), which interacts with glycogen synthase kinase 3, promotes cellular motility. H-prune also interacts with nm23-H1, a suppressor of cancer metastasis. It has been reported that stimulation of cellular motility by h-prune is enhanced by its interaction with nm23-H1 in breast cancer cells. In the present study, we examined the expression of h-prune and nm23-H1 during tumor progression in gastric cancer (GC). PRUNE mRNA was overexpressed in 12 (32%) of 38 GC cases by quantitative reverse transcription-polymerase chain reaction. PRUNE mRNA levels correlated significantly with advanced T grade, N grade and tumor stage. Immunohistochemical analysis revealed that 43 (30%) of 143 GC cases were positive for h-prune, and h-prune-positive GC cases showed more advanced T grade, N grade and tumor stage than h-prune-negative GC cases. One hundred and twenty-four (87%) of 143 GC cases were positive for nm23-H1, and nm23-H1 was expressed in almost all (42 cases, 98%) h-prune-positive GC cases. Many GC cases positive for both h-prune and nm23-H1 showed more advanced T grade, N grade and tumor stage than other type GC cases. Patients with h-prune-positive GC had a significantly worse survival rate than patients with h-prune-negative GC. These findings indicate that overexpression of h-prune is associated with tumor progression and aggressiveness of GC. nm23-H1 may enhance motility of cancer cells by interacting with h-prune. (Cancer Sci 2007; 98: 1198-1205)","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Blackwell Publishing"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1347-9032","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11808050","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"1198"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1205","bibliographicPageStart":"1198","bibliographicVolumeNumber":"98","bibliographic_titles":[{"bibliographic_title":"Cancer Science"},{"bibliographic_title":"Cancer Science"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.1349-7006.2007.00515.x","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1111/j.1349-7006.2007.00515.x","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"CancerScience_98-8_1198.pdf","filesize":[{"value":"963.5 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006556/files/CancerScience_98-8_1198.pdf"},"version_id":"9d639e0a-8ba4-4291-9499-3e392df1da04"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"20725"},"item_title":"Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2006556","relation_version_is_last":true,"title":["Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T07:52:54.557390+00:00"}