Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics.

Kitayama, Tomoya; Song, Liqiu; Morita, Katsuya; Dohi, Toshihiro

doi:10.1016/j.brainres.2006.04.033

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Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics.

https://hiroshima.repo.nii.ac.jp/records/2006531

名前 / ファイル	ライセンス	アクション
BrainRes_1096_97.pdf (293.9 KB)

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デフォルトアイテムタイプ_（フル）(1)

公開日

2023-03-18

タイトル

Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics.

言語

作成者

Kitayama, Tomoya
Song, Liqiu
Morita, Katsuya
Dohi, Toshihiro

アクセス権

open access

アクセス権URI

http://purl.org/coar/access_right/c_abf2

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主題Scheme

NDC

主題

490

内容記述

Alterations of norepinephrine transporter (NET) function by chroninc inhibition of NET in relation to sensitization to seizures induce by cocaine and local anesthetics were studied. [3H]norepinephrine up take into hippocampus region but not cortex, striatum or amygdalae isolated from mice treated daily for 5 days with desipramine, an inhibitor of NET was significantly decreased. Daily treatment of cocaine increased [3H]norepinephrine uptake into hippocampus. The decrease in norepinephrine uptake induced by chronic desipramine treatment was reversed by co-administration of lidocaine, bupivacaine or tricaine with desipramine. Daily administration of desipramine increased the incidence of appearance of lidocaine-induced convulsions and decreased that of cocaine-induced convulsions. The changes in the convulsive sensitivity to lidocaine and cocaine induced by repeated administration of desipramine was reversed by co-administration of lidocaine with desipramine. These results suggest that down-regulation of hippocampal NET induced by chronic administration of desipramine may be relevant to desipramine-induced sensitization of lidocaine convulsions. Inhibition of Na+ channels by local anesthetics may regulate desipramine-induced down-regulation of NET function. While repeated administration of cocaine caused up-regulation of hipoccampal NET function. Cocaine kindling developed by repeated administration of cocaine may be due to the different mechanisms from those for desipramine-induced sensitization of lidocaine seizures.

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出版者

Elsevier

言語

eng

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資源タイプ識別子

http://purl.org/coar/resource_type/c_6501

資源タイプ

journal article

出版タイプ

出版タイプResource

http://purl.org/coar/version/c_b1a7d7d4d402bcce

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2025-02-21 03:24:09.981875

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Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics.

× Kitayama, Tomoya

× Song, Liqiu

× Morita, Katsuya

× Dohi, Toshihiro

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