{"created":"2025-02-21T03:24:08.606024+00:00","id":2006531,"links":{},"metadata":{"_buckets":{"deposit":"716831c0-732c-43f9-9e77-5eaf78cd0dee"},"_deposit":{"created_by":41,"id":"2006531","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006531"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006531","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics.","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kitayama, Tomoya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kitayama","familyNameLang":"en"}],"givenNames":[{"givenName":"Tomoya","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Song, Liqiu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Song","familyNameLang":"en"}],"givenNames":[{"givenName":"Liqiu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Morita, Katsuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"Morita","familyNameLang":"en"}],"givenNames":[{"givenName":"Katsuya","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Dohi, Toshihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Dohi","familyNameLang":"en"}],"givenNames":[{"givenName":"Toshihiro","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2006 Elsevier Ltd."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Alterations of norepinephrine transporter (NET) function by chroninc inhibition of NET in relation to sensitization to seizures induce by cocaine and local anesthetics were studied. [3H]norepinephrine up take into hippocampus region but not cortex, striatum or amygdalae isolated from mice treated daily for 5 days with desipramine, an inhibitor of NET was significantly decreased. Daily treatment of cocaine increased [3H]norepinephrine uptake into hippocampus. The decrease in norepinephrine uptake induced by chronic desipramine treatment was reversed by co-administration of lidocaine, bupivacaine or tricaine with desipramine. Daily administration of desipramine increased the incidence of appearance of lidocaine-induced convulsions and decreased that of cocaine-induced convulsions. The changes in the convulsive sensitivity to lidocaine and cocaine induced by repeated administration of desipramine was reversed by co-administration of lidocaine with desipramine. These results suggest that down-regulation of hippocampal NET induced by chronic administration of desipramine may be relevant to desipramine-induced sensitization of lidocaine convulsions. Inhibition of Na+ channels by local anesthetics may regulate desipramine-induced down-regulation of NET function. While repeated administration of cocaine caused up-regulation of hipoccampal NET function. Cocaine kindling developed by repeated administration of cocaine may be due to the different mechanisms from those for desipramine-induced sensitization of lidocaine seizures.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0006-8993","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA0057324X","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"97"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-06-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"103","bibliographicPageStart":"97","bibliographicVolumeNumber":"1096","bibliographic_titles":[{"bibliographic_title":"Brain Research"},{"bibliographic_title":"Brain Research"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.brainres.2006.04.033","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"16725121","subitem_relation_type_select":"PMID"}},{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.brainres.2006.04.033","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"BrainRes_1096_97.pdf","filesize":[{"value":"293.9 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006531/files/BrainRes_1096_97.pdf"},"version_id":"9c04e332-cafa-4b86-a7b1-e7bef4a616d8"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"17044"},"item_title":"Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics.","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2006531","relation_version_is_last":true,"title":["Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics."],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T07:47:12.689457+00:00"}