| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2025-01-15 |
| タイトル |
|
|
タイトル |
Dysmorphic megakaryocytes in TAFRO syndrome: A case series from a single institute |
|
言語 |
en |
| 作成者 |
Maida, Shohei
Nakagawa, Hiromi
Ureshino, Hiroshi
Kajihara, Kyoko
Yamazaki, Shinichi
Ichinohe, Tatsuo
|
| アクセス権 |
|
|
アクセス権 |
embargoed access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is not the published version. Please cite only the published version. |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
TAFRO syndrome |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Bone marrow aspirate |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Dysmorphic megakaryocytes |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Megakaryocytes with bizarre nuclei |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Tocilizumab |
| 内容記述 |
|
|
内容記述 |
TAFRO syndrome is a rare systemic inflammatory disorder of unknown etiology characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. The diagnosis of TAFRO syndrome can be challenging; however, prompt diagnosis is vital because TAFRO syndrome is a progressive and life-threatening disease. We have showcased five patients with TAFRO syndrome who had similar bone marrow (BM) findings that could be considered the findings that characterize TAFRO syndrome. All patients were treated with corticosteroids and tocilizumab; three of the five patients (60 %) responded positively to the treatment. The unique BM findings observed in this study were megakaryocytes with distinct multinuclei and three-dimensional and indistinct bizarre nuclei (“dysmorphic megakaryocyte"), similar to the megakaryocyte morphology observed in myeloproliferative neoplasms (MPNs). Notably, dysmorphic megakaryocytes were observed in all five cases, whereas only two of the five patients tested positive for reticulin myelofibrosis, and three of the five patients had megakaryocytic hyperplasia, which are considered typical findings of TAFRO syndrome. Thus, the BM findings of dysmorphic megakaryocytes could help in the correct and immediate diagnosis of TAFRO syndrome. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported in part by the Program of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science of Hiroshima University, Nagasaki University, and Fukushima Medical University (to TI). |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.bcmd.2024.102870 |
| 開始ページ |
|
|
開始ページ |
102870 |
| 書誌情報 |
en : Blood Cells, Molecules, and Diseases
巻 108,
p. 102870,
発行日 2024-06-08
|
| 旧ID |
56116 |
| 備考 |
The full-text file will be made open to the public on 8 June 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving' |
BMD_108_102870.pdf (69.7 MB)
