{"created":"2025-02-21T03:23:14.790684+00:00","id":2006500,"links":{},"metadata":{"_buckets":{"deposit":"4193471d-61b8-42c8-9426-89c100d1edf0"},"_deposit":{"created_by":41,"id":"2006500","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006500"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006500","sets":["1730444907710"]},"author_link":[],"control_number":"2006500","item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Dysmorphic megakaryocytes in TAFRO syndrome: A case series from a single institute","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Maida, Shohei","creatorNameLang":"en"}],"familyNames":[{"familyName":"Maida","familyNameLang":"en"}],"givenNames":[{"givenName":"Shohei","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakagawa, Hiromi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nakagawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiromi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ureshino, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ureshino","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kajihara, Kyoko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kajihara","familyNameLang":"en"}],"givenNames":[{"givenName":"Kyoko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamazaki, Shinichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamazaki","familyNameLang":"en"}],"givenNames":[{"givenName":"Shinichi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ichinohe, Tatsuo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ichinohe","familyNameLang":"en"}],"givenNames":[{"givenName":"Tatsuo","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"},{"subitem_rights":"This is not the published version. Please cite only the published version.","subitem_rights_language":"en"},{"subitem_rights":"この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。","subitem_rights_language":"ja"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"TAFRO syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone marrow aspirate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dysmorphic megakaryocytes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Megakaryocytes with bizarre nuclei","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tocilizumab","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"TAFRO syndrome is a rare systemic inflammatory disorder of unknown etiology characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. The diagnosis of TAFRO syndrome can be challenging; however, prompt diagnosis is vital because TAFRO syndrome is a progressive and life-threatening disease. We have showcased five patients with TAFRO syndrome who had similar bone marrow (BM) findings that could be considered the findings that characterize TAFRO syndrome. All patients were treated with corticosteroids and tocilizumab; three of the five patients (60 %) responded positively to the treatment. The unique BM findings observed in this study were megakaryocytes with distinct multinuclei and three-dimensional and indistinct bizarre nuclei (“dysmorphic megakaryocyte\"), similar to the megakaryocyte morphology observed in myeloproliferative neoplasms (MPNs). Notably, dysmorphic megakaryocytes were observed in all five cases, whereas only two of the five patients tested positive for reticulin myelofibrosis, and three of the five patients had megakaryocytic hyperplasia, which are considered typical findings of TAFRO syndrome. Thus, the BM findings of dysmorphic megakaryocytes could help in the correct and immediate diagnosis of TAFRO syndrome.","subitem_description_language":"en"},{"subitem_description":"This work was supported in part by the Program of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science of Hiroshima University, Nagasaki University, and Fukushima Medical University (to TI).","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"102870"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"102870","bibliographicVolumeNumber":"108","bibliographic_titles":[{"bibliographic_title":"Blood Cells, Molecules, and Diseases","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bcmd.2024.102870","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-01-15"}],"displaytype":"simple","fileDate":[{"fileDateType":"Available","fileDateValue":"2025-06-08"}],"filename":"BMD_108_102870.pdf","filesize":[{"value":"69.7 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006500/files/BMD_108_102870.pdf"},"version_id":"643b4920-956f-4793-8072-1d08212f107c"}]},"item_title":"Dysmorphic megakaryocytes in TAFRO syndrome: A case series from a single institute","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-01-15"},"publish_date":"2025-01-15","publish_status":"0","recid":"2006500","relation_version_is_last":true,"title":["Dysmorphic megakaryocytes in TAFRO syndrome: A case series from a single institute"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-06-24T00:56:39.104628+00:00"}