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アイテム
多型性のないT細胞レセプターとCD1d分子のシグナル遮断は血液型A型抗原に対する抗体産生を特異的に抑制する
https://hiroshima.repo.nii.ac.jp/records/2005055
https://hiroshima.repo.nii.ac.jp/records/20050552d941b73-5b5d-4696-93a1-b4776da6144e
| 名前 / ファイル | ライセンス | アクション |
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k6271_3.pdf (1.3 MB)
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k6271_1.pdf (313.0 KB)
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k6271_2.pdf (172.7 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2014-11-21 | |||||||||
| タイトル | ||||||||||
| タイトル | Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates | |||||||||
| 言語 | en | |||||||||
| タイトル | ||||||||||
| タイトル | 多型性のないT細胞レセプターとCD1d分子のシグナル遮断は血液型A型抗原に対する抗体産生を特異的に抑制する | |||||||||
| 言語 | ja | |||||||||
| 作成者 |
田澤, 宏文
× 田澤, 宏文
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 権利情報 | ||||||||||
| 権利情報 | Copyright(c) by Author | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | Previously, we detected B cells expressing receptors for blood group A carbohydrates in the CD11b+CD5+ B-1a subpopulation in mice, similar to that in blood group O or B in humans. In the present study, we demonstrated that CD1d-restricted natural killer T (NKT) cells are required to produce anti-A antibodies (Abs), probably through collaboration with B-1a cells. After immunization of wild-type (WT) mice with human blood group A red blood cells (A-RBCs), interleukin (IL)-5 exclusively and transiently increased, and the anti-A Abs were elevated in sera; however, those were not observed at all in CD1d-/- mice, which lack NKT cells. Administration of anti-mouse CD1d blocking mAb prior to the immunization abolished IL-5 production by NKT cells and anti-A Ab production in WT mice. Administration of anti-IL-5 neutralizing mAb also diminished anti-A Ab production in WT mice, suggesting that IL-5 secreted from NKT cells critically regulates anti-A Ab production by B-1a cells. In NOD/SCID/γc null mice, into which peripheral blood mononuclear cells from type O human volunteers were engrafted, administration of anti-human CD1d mAb prior to the A-RBC immunization completely inhibited anti-A Ab production. Thus, anti-CD1d treatment might constitute a novel approach that could help in evading Ab-mediated rejection in ABOincompatible transplants. | |||||||||
| 言語 | en | |||||||||
| 日付 | ||||||||||
| 日付 | 2014-11-21 | |||||||||
| 日付タイプ | Created | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | NA | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||
| 関連情報 | ||||||||||
| 関連タイプ | references | |||||||||
| 関連名称 | Hirofumi Tazawa, Toshimitsu Irei, Yuka Tanaka, Yuka Igarashi, Hirotaka Tashiro and Hideki Ohdan; Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates; Blood 2013, 122(15):2582-2590 (doi: 10.1182/blood-2012-02-407452) | |||||||||
| 関連情報 | ||||||||||
| 関連タイプ | references | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | http://dx.doi.org/10.1182/blood-2012-02-407452 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第6271号 | |||||||||
| 学位名 | ||||||||||
| 言語 | ja | |||||||||
| 学位名 | 博士(医学) | |||||||||
| 学位名 | ||||||||||
| 言語 | en | |||||||||
| 学位名 | Philosophy in Medical Science | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2013-11-28 | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関識別子 | 15401 | |||||||||
| 言語 | ja | |||||||||
| 学位授与機関名 | 広島大学 | |||||||||
| 学位授与機関 | ||||||||||
| 言語 | en | |||||||||
| 学位授与機関名 | Hiroshima University | |||||||||
| 旧ID | 36279 | |||||||||
