{"created":"2025-02-18T10:00:01.577482+00:00","id":2005055,"links":{},"metadata":{"_buckets":{"deposit":"9238055f-f39d-4b22-98eb-25a690e93ba0"},"_deposit":{"created_by":41,"id":"2005055","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2005055"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02005055","sets":["1730444908512:1730444915582"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates","subitem_title_language":"en"},{"subitem_title":"多型性のないT細胞レセプターとCD1d分子のシグナル遮断は血液型A型抗原に対する抗体産生を特異的に抑制する","subitem_title_language":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田澤, 宏文","creatorNameLang":"ja"},{"creatorName":"Tazawa, Hirofumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"田澤","familyNameLang":"ja"},{"familyName":"Tazawa","familyNameLang":"en"}],"givenNames":[{"givenName":"宏文","givenNameLang":"ja"},{"givenName":"Hirofumi","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright(c) by Author"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Previously, we detected B cells expressing receptors for blood group A carbohydrates in the CD11b+CD5+ B-1a subpopulation in mice, similar to that in blood group O or B in humans. In the present study, we demonstrated that CD1d-restricted natural killer T (NKT) cells are required to produce anti-A antibodies (Abs), probably through collaboration with B-1a cells. After immunization of wild-type (WT) mice with human blood group A red blood cells (A-RBCs), interleukin (IL)-5 exclusively and transiently increased, and the anti-A Abs were elevated in sera; however, those were not observed at all in CD1d-/- mice, which lack NKT cells. Administration of anti-mouse CD1d blocking mAb prior to the immunization abolished IL-5 production by NKT cells and anti-A Ab production in WT mice. Administration of anti-IL-5 neutralizing mAb also diminished anti-A Ab production in WT mice, suggesting that IL-5 secreted from NKT cells critically regulates anti-A Ab production by B-1a cells. In NOD/SCID/γc null mice, into which peripheral blood mononuclear cells from type O human volunteers were engrafted, administration of anti-human CD1d mAb prior to the A-RBC immunization completely inhibited anti-A Ab production. Thus, anti-CD1d treatment might constitute a novel approach that could help in evading Ab-mediated rejection in ABOincompatible transplants.","subitem_description_language":"en"}]},"item_1617186660861":{"attribute_name":"Date","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-11-21","subitem_date_issued_type":"Created"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617187087799":{"attribute_name":"Dissertation Number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第6271号"}]},"item_1617187112279":{"attribute_name":"Degree Name","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_1617187136212":{"attribute_name":"Date Granted","attribute_value_mlt":[{"subitem_dategranted":"2013-11-28"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Hirofumi Tazawa, Toshimitsu Irei, Yuka Tanaka, Yuka Igarashi, Hirotaka Tashiro and Hideki Ohdan; Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates; Blood 2013, 122(15):2582-2590 (doi: 10.1182/blood-2012-02-407452) "}],"subitem_relation_type":"references"},{"subitem_relation_type":"references","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1182/blood-2012-02-407452","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-11-21"}],"displaytype":"simple","filename":"k6271_3.pdf","filesize":[{"value":"1.3 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2005055/files/k6271_3.pdf"},"version_id":"07b74424-209d-497e-a351-8938846ef363"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-11-21"}],"displaytype":"simple","filename":"k6271_1.pdf","filesize":[{"value":"313.0 KB"}],"mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://hiroshima.repo.nii.ac.jp/record/2005055/files/k6271_1.pdf"},"version_id":"65ee3286-7950-44ab-828d-a92fce15a5f7"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-11-21"}],"displaytype":"simple","filename":"k6271_2.pdf","filesize":[{"value":"172.7 KB"}],"mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://hiroshima.repo.nii.ac.jp/record/2005055/files/k6271_2.pdf"},"version_id":"4e15590e-7504-4656-b096-e4f592b492d3"}]},"item_1617944105607":{"attribute_name":"Degree Grantor","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"広島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"15401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]},{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Hiroshima University"}]}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"36279"},"item_title":"Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates","item_type_id":"40003","owner":"41","path":["1730444915582"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-11-21"},"publish_date":"2014-11-21","publish_status":"0","recid":"2005055","relation_version_is_last":true,"title":["Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-20T07:25:37.621916+00:00"}