WEKO3
アイテム
TIMP-1 c.T372C遺伝子多型による急性大動脈解離の予測可能性
https://hiroshima.repo.nii.ac.jp/records/2005027
https://hiroshima.repo.nii.ac.jp/records/20050271a587c18-bd2a-4ef9-b0c9-fb7167dcd1a9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
k6245_3.pdf (399.0 KB)
|
||
|
k6245_1.pdf (178.3 KB)
|
||
|
k6245_2.pdf (165.8 KB)
|
| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2014-11-25 | |||||||
| タイトル | ||||||||
| タイトル | TIMP-1 c.T372C Genetic Polymorphism as a Possible Predictor for Acute Aortic Dissection | |||||||
| 言語 | en | |||||||
| タイトル | ||||||||
| タイトル | TIMP-1 c.T372C遺伝子多型による急性大動脈解離の予測可能性 | |||||||
| 言語 | ja | |||||||
| 作成者 |
Naychov, Zheko Dimitrov
× Naychov, Zheko Dimitrov
|
|||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Aortic dissection | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | SNP | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | TIMP-1 | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | While single nucleotide polymorphisms (SNP) have been extensively researched in atherosclerotic aortic aneurysms, there are too few data about acute aortic dissection (AAD). The matrix metalloproteinase regulation system has shown a high biological relevance to the development of aortic aneurysms and AAD. The TIMP-1 c.T372C (rs4898, nt+434) SNP was previously associated with the onset of abdominal aortic and other aneurysms. Therefore, we chose this SNP to search for a connection with AAD and to find its place among the other risk factors. 115 patients with AAD were studied for their TIMP-1 c.T372C genotype by means of conventional restrictase analysis. To confirm the biological relevance of our findings, immunohistochemistry for TIMP-1 was performed on tissue samples from the same patients with AAD and compared with a control group of 23 autopsy cases. The TIMP-1 c.T372C showed a significant difference in allele frequency in the AAD patients compared to the general population (p < 0.0001 for both sexes). This genotype did not show any association with any other co-morbid condition, nor with age. The immunohistochemistry results also showed significantly lower TIMP-1 expression in the dissected aortas. The C allele of TIMP-1 c.T372C shows a strong association with the onset of AAD. | |||||||
| 言語 | en | |||||||
| 日付 | ||||||||
| 日付 | 2014-11-25 | |||||||
| 日付タイプ | Created | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | NA | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||
| 関連情報 | ||||||||
| 関連タイプ | references | |||||||
| 関連名称 | Zheko Dimirtov Naychov, Eiso Hiyama, Naomichi Uchida, Koji Arihiro, Masataka Nagao, Shinya Takahashi, Konstantin Vassilev Delchev and Taijiro Sueda; TIMP-1 c.T372C Genetic Polymorphism as a Possible Predictor for Acute Aortic Dissection; Hiroshima J. Med. Sci. Vol.62, No.2, 31-37, June, 2013 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第6245号 | |||||||
| 学位名 | ||||||||
| 言語 | ja | |||||||
| 学位名 | 博士(医学) | |||||||
| 学位名 | ||||||||
| 言語 | en | |||||||
| 学位名 | Philosophy in Medical Science | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2013-09-25 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 15401 | |||||||
| 言語 | ja | |||||||
| 学位授与機関名 | 広島大学 | |||||||
| 学位授与機関 | ||||||||
| 言語 | en | |||||||
| 学位授与機関名 | Hiroshima University | |||||||
| 旧ID | 36322 | |||||||
